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    Tgoln2 trans-golgi network protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192152, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tgoln2provided by RGD
    Official Full Name
    trans-golgi network protein 2provided by RGD
    Primary source
    RGD:620445
    See related
    EnsemblRapid:ENSRNOG00000014617 AllianceGenome:RGD:620445
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tgn38; Ttgn1; Tgoln1
    Summary
    Predicted to be involved in Golgi to endosome transport. Located in trans-Golgi network. Is active in glutamatergic synapse and postsynaptic Golgi apparatus. Orthologous to human TGOLN2 (trans-golgi network protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 547.2), Lung (RPKM 546.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tgoln2 in Genome Data Viewer
    Location:
    4q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (106221503..106229360, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104663356..104671208, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (100475415..100483229, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ELMO domain containing 3 Neighboring gene retinol saturase Neighboring gene uncharacterized LOC102549526 Neighboring gene transcription factor 7 like 1 Neighboring gene uncharacterized LOC102549458

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification, molecular characterization and immunolocalization of an isoform of the trans-Golgi-network (TGN)-specific integral membrane protein TGN38. Reaves B, et al. Biochem J, 1992 Apr 15. PMID 1575675, Free PMC Article
    2. Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38). Luzio JP, et al. Biochem J, 1990 Aug 15. PMID 2204342, Free PMC Article
    3. Efficient trafficking of TGN38 from the endosome to the trans-Golgi network requires a free hydroxyl group at position 331 in the cytosolic domain. Roquemore EP, et al. Mol Biol Cell, 1998 Aug. PMID 9693371, Free PMC Article
    4. Rapid dendritic transport of TGN38, a putative cargo receptor. McNamara JO 2nd, et al. Brain Res Mol Brain Res, 2004 Aug 23. PMID 15306122
    5. Serine 331 and tyrosine 333 are both involved in the interaction between the cytosolic domain of TGN38 and the mu2 subunit of the AP2 clathrin adaptor complex. Stephens DJ, et al. J Biol Chem, 1997 May 30. PMID 9162036

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108592

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    trans-Golgi network integral membrane protein TGN38
    Names
    trans-golgi network protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138840.3 → NP_620195.1  trans-Golgi network integral membrane protein TGN38 precursor

      See identical proteins and their annotated locations for NP_620195.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P19814, Q4G0B6
      UniProtKB/TrEMBL
      A0A8I6AQW2, A6IAD1
      Related
      ENSRNOP00000019713.5, ENSRNOT00000019713.8
      Conserved Domains (1) summary
      pfam09528
      Location:23 → 303
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      106221503..106229360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592426.3 → XP_017447915.1  trans-Golgi network integral membrane protein TGN38 isoform X2

      UniProtKB/TrEMBL
      Q63575

    2. XM_063285461.1 → XP_063141531.1  trans-Golgi network integral membrane protein TGN38 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQW2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19814.1 GenPept UniProtKB/Swiss-Prot:P19814

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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    Tools
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