Nppa natriuretic peptide A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nppaprovided by RGD
Official Full Name: natriuretic peptide Aprovided by RGD
Primary source: RGD:3193
See related: EnsemblRapid:ENSRNOG00000008176 AllianceGenome:RGD:3193
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ANF; ANP; CDD; Pnd; RATANF
Summary: Enables hormone activity. Involved in several processes, including cGMP biosynthetic process; positive regulation of cell communication; and regulation of monoatomic cation transmembrane transport. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in brush border; mast cell granule; and perinuclear region of cytoplasm. Is active in glycinergic synapse. Used to study congestive heart failure; pulmonary hypertension; and ureteral obstruction. Biomarker of acute kidney failure; artery disease (multiple); hypertrophic cardiomyopathy; and nephrosis. Human ortholog(s) of this gene implicated in artery disease (multiple); heart conduction disease (multiple); and peritonitis. Orthologous to human NPPA (natriuretic peptide A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 15587.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (163712184..163713493)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (158429042..158430351)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (164808407..164809716)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Underlying mechanism of atrial fibrillation-associated Nppa-I137T mutation and cardiac effect of potential drug therapy.
Title: Underlying mechanism of atrial fibrillation-associated Nppa-I137T mutation and cardiac effect of potential drug therapy.
Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.
Title: Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.
Nitric oxide acutely modulates hypothalamic and neurohypophyseal carbon monoxide and hydrogen sulphide production to control vasopressin, oxytocin and atrial natriuretic peptide release in rats.
Title: Nitric oxide acutely modulates hypothalamic and neurohypophyseal carbon monoxide and hydrogen sulphide production to control vasopressin, oxytocin and atrial natriuretic peptide release in rats.
Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1A and PPAR-gamma pathway.
Title: Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway.
These results indicate that endogenous ET-1 induced by hypoxia promotes hypoxia-induced ANP secretion by activation of COX2-L-PGDS-PPARgamma signaling in beating rat atria
Title: Endogenous ET-1 promotes ANP secretion through activation of COX2-L-PGDS-PPARγ signaling in hypoxic beating rat atria.
exocrine pancreas is relatively important extracardiac source
Title: The exocrine pancreas is an extracardiac source of atrial natriuretic peptide.
this study directly demonstrated the thermogenic actions of ANP in brown adipocytes through the use of a novel method of intracellular temperature measurement.
Title: The thermogenic actions of natriuretic peptide in brown adipocytes: The direct measurement of the intracellular temperature using a fluorescent thermoprobe.
we suggest that the order of secretagogue effect of ET family on ANP secretion was ET-1>/=ET-2>>ET-3>s6C and ET-1-induced atrial natriuretic peptide secretion negatively regulates the pressor effect of ET-1.
Title: Effects of endothelin family on ANP secretion.
Despite preserved LV structure and function, treatment with GYY increased the levels of the natriuretic peptides ANP and BNP in association with enhanced cyclic GMP levels, paralleled by higher cGMP-dependent protein kinase type I (cGKI) protein levels
Title: GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia.
Angiotensin IV stimulates ANP secretion and concentration via the IRAP and PI3K-Akt-mTOR signaling pathway.
Title: Angiotensin IV stimulates high atrial stretch-induced ANP secretion via insulin regulated aminopeptidase.

Submit: New GeneRIF Correction See all GeneRIFs (70)

General gene information

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Markers

D5Wox10 (e-PCR)
- UniSTS:118091

RH127740 (e-PCR)
- UniSTS:211050

PMC123178P1 (e-PCR)
- UniSTS:270444

PMC316718P1 (e-PCR)
- UniSTS:273041

RH94452 (e-PCR)
- UniSTS:119700

NoName (e-PCR)
- UniSTS:547523

Nppa (e-PCR), detects polymorphism
- UniSTS:547523

BI280386 (e-PCR)
- UniSTS:249035

d5mit15 (e-PCR)
- UniSTS:122068

Nppa (e-PCR), detects polymorphism
- UniSTS:167638

PMC15566P1 (e-PCR)
- UniSTS:271346

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor binding	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cGMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in cell growth involved in cardiac muscle cell development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in multicellular organismal-level water homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of collecting lymphatic vessel constriction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of systemic arterial blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of histamine secretion by mast cell	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of potassium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor guanylyl cyclase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	TAS Traceable Author Statement more info	PubMed
involved_in regulation of body fluid levels	TAS Traceable Author Statement more info	PubMed
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of high voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to 3-methylcholanthrene	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sodium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in synaptic signaling via neuropeptide	EXP Inferred from Experiment more info	PubMed
involved_in synaptic signaling via neuropeptide	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic signaling via neuropeptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasodilation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glycinergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glycinergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mast cell granule	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: natriuretic peptides A

Names: Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); atrial natriuretic factor prohormone; atrial natriuretic peptide prohormone; atriopeptigen; cardiodilatin; natriuretic peptide precursor type A; preproANF; preproANP; preproCDD-ANF; prepronatriodilatin; proANF; proANP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.