Chp2 calcineurin-like EF hand protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chp2provided by RGD
Official Full Name: calcineurin-like EF hand protein 2provided by RGD
Primary source: RGD:727796
See related: EnsemblRapid:ENSRNOG00000019112 AllianceGenome:RGD:727796
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: chp-2
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including positive regulation of calcineurin-NFAT signaling cascade; positive regulation of phosphatase activity; and positive regulation of protein import into nucleus. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human CHP2 (calcineurin like EF-hand protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 26.1), Muscle (RPKM 24.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (186189090..186203663)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (176757945..176772443)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (192169634..192173228)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calcineurin B isoforms showed increased expression throughout the CA1 and CA2 while there was a decrease in expression within the ipsilateral dentate gyrus.
Title: Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury.
CHP2 is predominantly expressed in epithelial cells of the small and large intestine where it may regulate epithelial Na+/H+ exchanger(NHE)isoforms NHE2-4.
Title: Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular sodium ion homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular pH	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcineurin B homologous protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182738.1 → NP_877402.1 calcineurin B homologous protein 2

See identical proteins and their annotated locations for NP_877402.1

Status: PROVISIONAL

Source sequence(s)

AB086189

UniProtKB/Swiss-Prot

Q810D1

Conserved Domains (1) summary

COG5126
Location:23 → 179

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

186189090..186203663

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078237.2 → XP_038934165.1 calcineurin B homologous protein 2 isoform X1

UniProtKB/TrEMBL

A0A8L2QDX2

Related

ENSRNOP00000025832.5, ENSRNOT00000025832.7

Conserved Domains (1) summary

COG5126
Location:79 → 235

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_017589206.3 → XP_017444695.1 calcineurin B homologous protein 2 isoform X2

UniProtKB/Swiss-Prot

Q810D1

Conserved Domains (1) summary

COG5126
Location:23 → 179

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_008759746.4 → XP_008757968.1 calcineurin B homologous protein 2 isoform X2

See identical proteins and their annotated locations for XP_008757968.1

UniProtKB/Swiss-Prot

Q810D1

Related

ENSRNOP00000107025.1, ENSRNOT00000163431.1

Conserved Domains (1) summary

COG5126
Location:23 → 179

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]