Bbof1 basal body orientation factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bbof1provided by RGD
Official Full Name: basal body orientation factor 1provided by RGD
Primary source: RGD:1560978
See related: EnsemblRapid:ENSRNOG00000011376 AllianceGenome:RGD:1560978
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdc176; RGD1560978
Summary: Predicted to be involved in sperm axoneme assembly. Predicted to be located in axoneme and sperm flagellum. Orthologous to human BBOF1 (basal body orientation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1049.3), Liver (RPKM 591.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (109786363..109812153)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (104055246..104081036)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (108123855..108149613)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium movement involved in cell motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within single fertilization	ISO Inferred from Sequence Orthology more info
involved_in sperm axoneme assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axoneme	ISO Inferred from Sequence Orthology more info
is_active_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: basal body-orientation factor 1

Names: coiled-coil domain containing 176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395618.1 → NP_001382547.1 basal body-orientation factor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6G3Y3

Related

ENSRNOP00000059292.2, ENSRNOT00000063900.3

Conserved Domains (1) summary

pfam14988
Location:75 → 268

DUF4515; Domain of unknown function (DUF4515)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

109786363..109812153

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262320.1 → XP_063118390.1 basal body-orientation factor 1 isoform X2
XM_008764830.4 → XP_008763052.3 basal body-orientation factor 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K4P4, A0A8I6G3Y3

Related

ENSRNOP00000073122.2, ENSRNOT00000089242.3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001134631.1: Suppressed sequence

Description

NM_001134631.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.