Cd180 CD180 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd180provided by RGD
Official Full Name: CD180 moleculeprovided by RGD
Primary source: RGD:1308170
See related: EnsemblRapid:ENSRNOG00000010266 AllianceGenome:RGD:1308170
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ly78; RP105
Summary: Predicted to be involved in B cell proliferation involved in immune response; cellular response to lipopolysaccharide; and positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in mitotic spindle; nuclear lumen; and plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human CD180 (CD180 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 189.8), Thymus (RPKM 27.8) and 4 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (35589889..35602837)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (33855940..33870046)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (32820275..32833223)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RP105 plays a cardioprotective role in myocardial ischemia reperfusion injury by regulating the Tolllike receptor 2/4 signaling pathways.
Title: RP105 plays a cardioprotective role in myocardial ischemia reperfusion injury by regulating the Toll‑like receptor 2/4 signaling pathways.
Inhibition of miR-141-3p reduced hypoxia-induced apoptosis in H9c2 cardiomyocytes in vitro by activating the RP105-dependent PI3K/AKT signaling pathway.
Title: Inhibition of microRNA-141-3p Reduces Hypoxia-Induced Apoptosis in H9c2 Rat Cardiomyocytes by Activating the RP105-Dependent PI3K/AKT Signaling Pathway.
RP105 was minimally expressed in cardiac microvascular endothelial cells subjected to hypoxiareoxygenation injury.
Title: RP105 ameliorates hypoxia̸reoxygenation injury in cardiac microvascular endothelial cells by suppressing TLR4̸MAPKs̸NF-κB signaling.
CD180 protected PC12 cells from oxygenglucose deprivation/reoxygenation injury through promotion of the PI3K/AKT pathway.
Title: RP105 protects PC12 cells from oxygen‑glucose deprivation/reoxygenation injury via activation of the PI3K/AKT signaling pathway.
Data show that overexpression of radioprotective 105 kDa protein (RP105; CD180) led to the repression of toll-like receptor 4 (TLR4) activity and the phosphorylation of NF-Kappa B p65.
Title: Radioprotective 105 kDa protein attenuates ischemia/reperfusion-induced myocardial apoptosis and autophagy by inhibiting the activation of the TLR4/NF-κB signaling pathway in rats.
the anti-inflammatory roles of radioprotective 105 kDa protein (RP105) and its potential in preventing and treating myocardial ischemia-reperfusion (I/R) injury.
Title: RP105 protects against myocardial ischemia-reperfusion injury via suppressing TLR4 signaling pathways in rat model.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

G46465 (e-PCR)
- UniSTS:107267

RH137386 (e-PCR)
- UniSTS:219474

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in B cell proliferation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell proliferation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: CD180 antigen

Names: lymphocyte antigen 78; radioprotective 105 kDa protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106405.2 → NP_001099875.1 CD180 antigen precursor

See identical proteins and their annotated locations for NP_001099875.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6I5D7, D3ZIP2

Related

ENSRNOP00000100934.1, ENSRNOT00000160951.1

Conserved Domains (4) summary

cd00116
Location:301 → 480

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:324 → 347

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:421 → 482

LRR_8; Leucine rich repeat

cl15307
Location:578 → 627

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

35589889..35602837

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101928.2 → XP_038957856.1 CD180 antigen isoform X1

Conserved Domains (6) summary

TIGR00864
Location:435 → 501

PCC; polycystin cation channel protein

sd00033
Location:209 → 232

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:306 → 367

LRR_8; Leucine rich repeat

pfam18831
Location:106 → 134

LRR_11; Leucine-rich repeat

NF033190
Location:29 → 214

inl_like_NEAT_1; NEAT domain-containing leucine-rich repeat protein

cl39015
Location:186 → 365

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...