Ugt2b7 UDP glucuronosyltransferase family 2 member B7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ugt2b7provided by RGD
Official Full Name: UDP glucuronosyltransferase family 2 member B7provided by RGD
Primary source: RGD:708417
See related: EnsemblRapid:ENSRNOG00000070682 AllianceGenome:RGD:708417
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ugt2b8; UDPGT 2B7
Summary: Predicted to enable glucuronosyltransferase activity. Predicted to be involved in androgen metabolic process; cellular glucuronidation; and estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human UGT2B7 (UDP glucuronosyltransferase family 2 member B7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 10.0), Liver (RPKM 8.3) and 3 other tissues See more
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Genomic context

Location:: 14p21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (21251535..21274451)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (20896682..20919604)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (22597103..22619968)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Meanwhile, only mitragynine and zerumbone inhibited ZDV(probe substrate to determine UGT2B7 activity) glucuronidation in RLM with IC50 values of 51.20 +/- 5.95 muM and 8.14 +/- 2.12 microM, respectively, indicating a difference between the human and rat microsomal model so caution must be exercised when extrapolating inhibitory metabolic data from rats to humans.
Title: Inhibition of UGT2B7 Enzyme Activity in Human and Rat Liver Microsomes by Herbal Constituents.
Acute liver failure significantly increases the oral plasma exposure of zidovudine in rats, a result partly attributed to the impaired function and expression of hepatic UGT2B7 and intestinal P-gp.
Title: Acute liver failure enhances oral plasma exposure of zidovudine in rats by downregulation of hepatic UGT2B7 and intestinal P-gp.
Data suggest that UGT2B7 is the predominant activity in liver microsomes for haloperidol O-glucuronidation (in both rat and human).
Title: Human UDP-glucuronosyltransferase isoforms involved in haloperidol glucuronidation and quantitative estimation of their contribution.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glucuronosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables retinoic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular glucuronidation	ISO Inferred from Sequence Orthology more info
involved_in cellular glucuronidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-glucuronosyltransferase 2B7

Names: UDP glucuronosyltransferase 2 family, polypeptide B7; UDP-glucuronosyltransferase 2B8; UDPGT 2B8; UGT2B-RH4

NP_775445.2

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173323.2 → NP_775445.2 UDP-glucuronosyltransferase 2B7 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q62789

UniProtKB/TrEMBL

A6JCQ2, F1LLV5

Related

ENSRNOP00000050445.5, ENSRNOT00000048482.6

Conserved Domains (1) summary

pfam00201
Location:24 → 527

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase