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    Slc24a3 solute carrier family 24 member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85267, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc24a3provided by RGD
    Official Full Name
    solute carrier family 24 member 3provided by RGD
    Primary source
    RGD:69256
    See related
    EnsemblRapid:ENSRNOG00000060687 AllianceGenome:RGD:69256
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nckx3
    Summary
    Enables calcium, potassium:sodium antiporter activity. Involved in monoatomic cation transport. Located in cell periphery. Orthologous to human SLC24A3 (solute carrier family 24 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 118.8), Uterus (RPKM 103.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc24a3 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (153005418..153504497)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (132552119..133051192)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (139333942..139835728)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486167 Neighboring gene D-aminoacyl-tRNA deacylase 1 Neighboring gene SCP2 sterol-binding domain containing 1 Neighboring gene uncharacterized LOC120101723 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108350484 Neighboring gene U4 spliceosomal RNA Neighboring gene Ras and Rab interactor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Uterine expression of sodium/potassium/calcium exchanger 3 and its regulation by sex-steroid hormones during the estrous cycle of rats. Yang H, et al. Mol Reprod Dev, 2010 Nov. PMID 21104767
    2. NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model. Yang H, et al. Mol Cell Endocrinol, 2017 Oct 15. PMID 28602864
    3. K+-dependent Na+/Ca2+ exchanger 3 is involved in renal active calcium transport and is differentially expressed in the mouse kidney. Lee GS, et al. Am J Physiol Renal Physiol, 2009 Aug. PMID 19474185
    4. Sodium/potassium/calcium exchanger 3 is regulated by the steroid hormones estrogen and progesterone in the uterus of mice during the estrous cycle. Yang H, et al. Biochem Biophys Res Commun, 2009 Jul 24. PMID 19464262
    5. Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle. Dong H, et al. Am J Physiol Heart Circ Physiol, 2006 Sep. PMID 16617138

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NCKX3 may be involved in reproductive function during the estrous cycle in female rats.
      Title: Uterine expression of sodium/potassium/calcium exchanger 3 and its regulation by sex-steroid hormones during the estrous cycle of rats.
    2. Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.
      Title: Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.
    3. mRNA encoding NCKX3 and NCKX4 was demonstrated by RT-PCR and Northern blot in both rat mesenteric and aortic smooth muscle providing evidence for their role in mediating vascular tone.
      Title: Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium, potassium:sodium antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium, potassium:sodium antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bone mineralization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium/potassium/calcium exchanger 3
    Names
    Na(+)/K(+)/Ca(2+)-exchange protein 3
    potassium-dependent sodium-calcium exchanger NCKX3 (SLC24A3)
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053505.3 → NP_445957.2  sodium/potassium/calcium exchanger 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q9EPQ0
      Related
      ENSRNOP00000093366.1, ENSRNOT00000115668.2
      Conserved Domains (2) summary
      TIGR00367
      Location:111 → 604
      TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
      pfam01699
      Location:112 → 254
      Na_Ca_ex; Sodium/calcium exchanger protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      153005418..153504497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106001.2 → XP_038961929.1  sodium/potassium/calcium exchanger 3 isoform X2

      UniProtKB/Swiss-Prot
      Q9EPQ0
      UniProtKB/TrEMBL
      A6K770
      Related
      ENSRNOP00000071351.2, ENSRNOT00000089098.3
      Conserved Domains (1) summary
      TIGR00927
      Location:39 → 578
      2A1904; K+-dependent Na+/Ca+ exchanger

    2. XM_063284741.1 → XP_063140811.1  sodium/potassium/calcium exchanger 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9EPQ0
      Related
      ENSRNOP00000110531.1, ENSRNOT00000158472.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPQ0.1 GenPept UniProtKB/Swiss-Prot:Q9EPQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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