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    Cttnbp2 cortactin binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282587, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cttnbp2provided by RGD
    Official Full Name
    cortactin binding protein 2provided by RGD
    Primary source
    RGD:628691
    See related
    EnsemblRapid:ENSRNOG00000061845 AllianceGenome:RGD:628691
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cbp90; Cortbp2
    Summary
    Enables SH3 domain binding activity. Involved in regulation of modification of postsynaptic actin cytoskeleton. Located in synaptic vesicle. Is active in glutamatergic synapse. Orthologous to human CTTNBP2 (cortactin binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 168.9), Adrenal (RPKM 67.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cttnbp2 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (47766867..47930598, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (46800975..46964681, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (42932897..43096454, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene CF transmembrane conductance regulator Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134486734 Neighboring gene uncharacterized LOC120102241 Neighboring gene U2 snRNP-associated SURP domain containing, pseudogene 1 Neighboring gene uncharacterized LOC134486735

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms. Shih PY, et al. Acta Neuropathol Commun, 2020 Nov 9. PMID 33168105, Free PMC Article
    2. Cortactin-binding protein 2 increases microtubule stability and regulates dendritic arborization. Shih PY, et al. J Cell Sci, 2014 Aug 15. PMID 24928895
    3. Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance. Chen YK, et al. J Neurosci, 2012 Jan 18. PMID 22262902, Free PMC Article
    4. Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90. Ohoka Y, et al. Genes Cells, 1998 Sep. PMID 9813110
    5. Comparative analyses of multi-species sequences from targeted genomic regions. Thomas JW, et al. Nature, 2003 Aug 14. PMID 12917688

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms.
      Title: Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms.
    2. Cttnbp2 increases microtubule stability and regulates dendritic arborization.
      Title: Cortactin-binding protein 2 increases microtubule stability and regulates dendritic arborization.
    3. This sst=udy demonistrated that Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance.
      Title: Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of modification of postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of FAR/SIN/STRIPAK complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cortactin-binding protein 2
    Names
    brain specific cortactin-binding protein CBP90

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114401.1 → NP_001107873.1  cortactin-binding protein 2

      See identical proteins and their annotated locations for NP_001107873.1

      Status: PROVISIONAL

      Source sequence(s)
      DP000027
      UniProtKB/Swiss-Prot
      O88864, Q2IBD4
      UniProtKB/TrEMBL
      A0A8I5YC08
      Related
      ENSRNOP00000072761.1, ENSRNOT00000087167.3
      Conserved Domains (8) summary
      PRK11331
      Location:1077 → 1357
      PRK11331; 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional
      cd00204
      Location:728 → 853
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam09486
      Location:108 → 258
      HrpB7; Bacterial type III secretion protein (HrpB7)
      pfam09727
      Location:36 → 179
      CortBP2; Cortactin-binding protein-2
      pfam12796
      Location:738 → 829
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:702 → 754
      Ank_4; Ankyrin repeats (many copies)
      pfam13863
      Location:135 → 228
      DUF4200; Domain of unknown function (DUF4200)
      sd00045
      Location:766 → 797
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      47766867..47930598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107159.2 → XP_038963087.1  cortactin-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5YC08
      Related
      ENSRNOP00000077746.1, ENSRNOT00000120156.2
      Conserved Domains (6) summary
      PRK11331
      Location:1036 → 1318
      PRK11331; 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional
      PHA03247
      Location:317 → 669
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:725 → 756
      ANK; ANK repeat [structural motif]
      pfam15921
      Location:134 → 476
      CCDC158; Coiled-coil domain-containing protein 158
      pfam09727
      Location:36 → 179
      CortBP2; Cortactin-binding protein-2
      pfam12796
      Location:697 → 791
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_017592494.3 → XP_017447983.1  cortactin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YC08

    3. XM_039107160.2 → XP_038963088.1  cortactin-binding protein 2 isoform X3

      Conserved Domains (6) summary
      PRK11331
      Location:1077 → 1267
      PRK11331; 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional
      PHA03247
      Location:272 → 703
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:766 → 797
      ANK; ANK repeat [structural motif]
      pfam15921
      Location:134 → 476
      CCDC158; Coiled-coil domain-containing protein 158
      pfam09727
      Location:36 → 179
      CortBP2; Cortactin-binding protein-2
      pfam12796
      Location:738 → 832
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_039107161.2 → XP_038963089.1  cortactin-binding protein 2 isoform X4

      Conserved Domains (6) summary
      PHA02874
      Location:702 → 909
      PHA02874; ankyrin repeat protein; Provisional
      PHA03247
      Location:276 → 703
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:766 → 797
      ANK; ANK repeat [structural motif]
      pfam15921
      Location:134 → 476
      CCDC158; Coiled-coil domain-containing protein 158
      pfam09727
      Location:36 → 179
      CortBP2; Cortactin-binding protein-2
      pfam12796
      Location:738 → 832
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_039107162.2 → XP_038963090.1  cortactin-binding protein 2 isoform X5

      Conserved Domains (5) summary
      PHA03247
      Location:276 → 703
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:702 → 731
      ANK; ANK repeat [structural motif]
      pfam15921
      Location:134 → 476
      CCDC158; Coiled-coil domain-containing protein 158
      pfam09727
      Location:36 → 179
      CortBP2; Cortactin-binding protein-2
      pfam12796
      Location:704 → 781
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2IBD4.1 GenPept UniProtKB/Swiss-Prot:Q2IBD4

    Gene LinkOut

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