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    Slc22a22 solute carrier family 22 member 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc22a22provided by RGD
    Official Full Name
    solute carrier family 22 member 22provided by RGD
    Primary source
    RGD:1304605
    See related
    EnsemblRapid:ENSRNOG00000004958 AllianceGenome:RGD:1304605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    oat-pg; RGD1304605
    Summary
    Predicted to enable prostaglandin receptor activity. Predicted to be involved in organic anion transport. Predicted to act upstream of or within sodium-independent prostaglandin transport. Predicted to be located in basolateral plasma membrane. Orthologous to human SLC22A10 (solute carrier family 22 member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 160.5) See more
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    Genomic context

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    See Slc22a22 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (90610007..90639718, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (88720425..88750111, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (97042176..97071984, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351495 Neighboring gene hyaluronan synthase 2 Neighboring gene catenin beta 1, pseudogene 1 Neighboring gene uncharacterized LOC134479732 Neighboring gene solute carrier family 25 member 5 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sex hormones induce a gender-related difference in renal expression of a novel prostaglandin transporter, OAT-PG, influencing basal PGE2 concentration. Hatano R, et al. Am J Physiol Renal Physiol, 2012 Feb 1. PMID 22031854
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OAT-PG is involved in local PGE(2) clearance in the renal cortex.
      Title: Sex hormones induce a gender-related difference in renal expression of a novel prostaglandin transporter, OAT-PG, influencing basal PGE2 concentration.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables prostaglandin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sodium-independent prostaglandin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 22
    Names
    prostaglandin transporter OAT-PG
    solute carrier family 22 (organic cation transporter), member 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013947.2 → NP_001013969.1  solute carrier family 22 member 22 isoform 1

      See identical proteins and their annotated locations for NP_001013969.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      F7F331, G3XEU5, Q66H77
      Related
      ENSRNOP00000006596.4, ENSRNOT00000006596.8
      Conserved Domains (2) summary
      cd06174
      Location:127 → 516
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 526
      2A0119; cation transport protein

    2. NM_001430350.1 → NP_001417279.1  solute carrier family 22 member 22 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      F7F331, G3XEU5, Q66H77

    3. NM_001430351.1 → NP_001417280.1  solute carrier family 22 member 22 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      G3XEU5

    4. NM_001430352.1 → NP_001417281.1  solute carrier family 22 member 22 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      G3XEU5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      90610007..90639718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263255.1 → XP_063119325.1  solute carrier family 22 member 22 isoform X3

    2. XM_063263253.1 → XP_063119323.1  solute carrier family 22 member 22 isoform X1

    3. XM_063263254.1 → XP_063119324.1  solute carrier family 22 member 22 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools