F2r coagulation factor II (thrombin) receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25439, updated on 9-Dec-2024

Summary

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Official Symbol: F2rprovided by RGD
Official Full Name: coagulation factor II (thrombin) receptorprovided by RGD
Primary source: RGD:2586
See related: EnsemblRapid:ENSRNOG00000048043 AllianceGenome:RGD:2586
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Par1; TRGPC
Summary: Predicted to enable several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and thrombin-activated receptor activity. Involved in several processes, including establishment of synaptic specificity at neuromuscular junction; negative regulation of glomerular filtration; and positive regulation of vasoconstriction. Located in neuromuscular junction and postsynaptic membrane. Used to study hypertension. Biomarker of brain edema and brain ischemia. Orthologous to human F2R (coagulation factor II thrombin receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 362.8), Adrenal (RPKM 230.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See F2r in Genome Data Viewer

Location:: 2q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (28604066..28620579, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (26869343..26885856, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (26118760..26135340, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elucidating PAR1 as a therapeutic target for delayed traumatic brain injury: Unveiling the PPAR-gamma/Nrf2/HO-1/GPX4 axis to suppress ferroptosis and alleviate NLRP3 inflammasome activation in rats.
Title: Elucidating PAR1 as a therapeutic target for delayed traumatic brain injury: Unveiling the PPAR-γ/Nrf2/HO-1/GPX4 axis to suppress ferroptosis and alleviate NLRP3 inflammasome activation in rats.
Protease-Activated Receptor 1-Mediated Damage of Podocytes in Diabetic Nephropathy.
Title: Protease-Activated Receptor 1-Mediated Damage of Podocytes in Diabetic Nephropathy.
Cell Responses of the Ventrolateral Medulla to PAR1 Activation and Changes in Respiratory Rhythm in Newborn Rat En Bloc Brainstem-Spinal Cord Preparations.
Title: Cell Responses of the Ventrolateral Medulla to PAR1 Activation and Changes in Respiratory Rhythm in Newborn Rat En Bloc Brainstem-Spinal Cord Preparations.
Early growth response factor 1 upregulates pro-fibrotic genes through activation of TGF-beta1/Smad pathway via transcriptional regulation of PAR1 in high-glucose treated HK-2 cells.
Title: Early growth response factor 1 upregulates pro-fibrotic genes through activation of TGF-β1/Smad pathway via transcriptional regulation of PAR1 in high-glucose treated HK-2 cells.
TRAP-induced PAR1 expression with its mechanism during AMI in a rat model.
Title: TRAP-induced PAR1 expression with its mechanism during AMI in a rat model.
Role of protease-activated receptor-1 (PAR-1) in the glomerular filtration barrier integrity.
Title: Role of protease-activated receptor-1 (PAR-1) in the glomerular filtration barrier integrity.
Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1.
Title: Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1.
Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activity.
Title: Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activity.
Role of proteinase-activated receptors 1 and 2 in nonsteroidal anti-inflammatory drug enteropathy.
Title: Role of proteinase-activated receptors 1 and 2 in nonsteroidal anti-inflammatory drug enteropathy.
Protease-activated receptor 1 inhibitor improves brain edema in rats with intracerebral hemorrhage.
Title: Protease-activated receptor 1 inhibitor improves brain edema in rats with intracerebral hemorrhage.

Submit: New GeneRIF Correction See all GeneRIFs (73)

General gene information

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Markers

PMC156147P9 (e-PCR)
- UniSTS:271386

RH94524 (e-PCR)
- UniSTS:119772

RH140970 (e-PCR)
- UniSTS:222971

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables G-protein beta-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta-subunit binding	ISO Inferred from Sequence Orthology more info
enables G-protein beta-subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables thrombin-activated receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thrombin-activated receptor activity	IEA Inferred from Electronic Annotation more info
enables thrombin-activated receptor activity	ISO Inferred from Sequence Orthology more info
enables thrombin-activated receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables thrombin-activated receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell junction maintenance	IEA Inferred from Electronic Annotation more info
involved_in cell-cell junction maintenance	ISO Inferred from Sequence Orthology more info
involved_in connective tissue replacement involved in inflammatory response wound healing	IEA Inferred from Electronic Annotation more info
involved_in connective tissue replacement involved in inflammatory response wound healing	ISO Inferred from Sequence Orthology more info
involved_in connective tissue replacement involved in inflammatory response wound healing	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic cell homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendritic cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in establishment of synaptic specificity at neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
involved_in homeostasis of number of cells within a tissue	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
involved_in homeostasis of number of cells within a tissue	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glomerular filtration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of renin secretion into blood stream	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of renin secretion into blood stream	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of renin secretion into blood stream	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
involved_in platelet activation	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood coagulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vasoconstriction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISS Inferred from Sequence or Structural Similarity more info
involved_in thrombin-activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thrombin-activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in thrombin-activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in thrombin-activated receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in platelet dense tubular network	IEA Inferred from Electronic Annotation more info
located_in platelet dense tubular network	ISO Inferred from Sequence Orthology more info
located_in platelet dense tubular network	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteinase-activated receptor 1

Names: PAR-1; Thrombin receptor; coagulation factor II receptor; protease-activated receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012950.2 → NP_037082.2 proteinase-activated receptor 1 precursor

Status: VALIDATED

Source sequence(s)

BC085759, CV116337

UniProtKB/Swiss-Prot

P26824

UniProtKB/TrEMBL

A0A9K3Y7Y4, M0R834, Q5U324

Related

ENSRNOP00000065624.3, ENSRNOT00000074626.4

Conserved Domains (1) summary

cd15369
Location:110 → 389

7tmA_PAR1; protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors