Cat catalase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Catprovided by RGD
Official Full Name: catalaseprovided by RGD
Primary source: RGD:2279
See related: EnsemblRapid:ENSRNOG00000008364 AllianceGenome:RGD:2279
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CS1; Cas1; Catl; Cs-1; Cat01
Summary: Enables catalase activity. Involved in several processes, including hydrogen peroxide catabolic process; response to L-ascorbic acid; and response to vitamin E. Located in extracellular space and peroxisomal matrix. Used to study brain ischemia; cholestasis; colitis; and lung disease (multiple). Biomarker of several diseases, including alcohol use disorder; artery disease (multiple); auditory system disease (multiple); eye disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 3517.9), Kidney (RPKM 1744.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (110297340..110329526, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (89842393..89874577, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (93379872..93412058, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex.
Title: Antioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stress.
fenofibrate almost completely abolished GM-induced reactive oxygen species generation, which seemed to be mediated at least in part by the restoration of the expression of PPARalphadependent antioxidant enzymes, including catalase and superoxide dismutase (SOD)-1.
Title: Fenofibrate exerts protective effects against gentamicin-induced toxicity in cochlear hair cells by activating antioxidant enzymes.
These results indicate that CAT expression is significantly decreased in the hippocampi of aged animals and decreased CAT expression may be closely associated with aging.
Title: Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats.
Catalase promoter region (-185 to +52) that contains binding sites for C/EBP-beta showed an augmentation in the methylation level along with a change in methylation pattern of CpG islands in response to PTU treatment
Title: Neonatal Persistent Exposure to 6-Propyl-2-thiouracil, a Thyroid-Disrupting Chemical, Differentially Modulates Expression of Hepatic Catalase and C/EBP-β in Adult Rats.
Data show that nuclear factor erythroid 2-related factor (Nrf2), superoxide dismutase Sod1 and catalase antioxidant systems are downregulated in isolated arteries and vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats (SHRSP).
Title: Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension.
mitochondria-targeted antioxidant SkQ1 (50 nmol/kg during 5 days) significantly increased the mRNA levels of Nrf2 transcription factor and Nrf2-induced genes encoding antioxidant enzymes SOD1, SOD2, CAT, and GPx4 in rat peripheral blood leukocytes.
Title: Influence of SkQ1 on Expression of Nrf2 Transcription Factor Gene, ARE-Controlled Genes of Antioxidant Enzymes and Their Activity in Rat Blood Leukocytes.
Targeted mass spectrometry for the analysis of nutritive modulation of catalase and heme oxygenase-1 expression.
Title: Targeted mass spectrometry for the analysis of nutritive modulation of catalase and heme oxygenase-1 expression.
Decrease in Sirtuin1 (SIRT1) and nuclear factor erythroid 2-related factor (Nrf2) and increase in nuclear factor kappa B (NFkappaB) gene expression in diabetes were associated with a decrease in CAT and GPx mRNA expression.
Title: Redox regulation of antioxidant enzymes: post-translational modulation of catalase and glutathione peroxidase activity by resveratrol in diabetic rat liver.
Coronary resistance regulation seems to be more dependent on the hydrogen peroxide that is maintained at low levels by increased catalase activity.
Title: Catalase influence in the regulation of coronary resistance by estrogen: joint action of nitric oxide and hydrogen peroxide.
Catalase was found to participate in lead-induced alcohol intake and is elevated in blood following lead exposure.
Title: Participation of catalase in voluntary ethanol consumption in perinatally low-level lead-exposed rats.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Mit7 (e-PCR), detects polymorphism
- UniSTS:119377

D3Hmgc1 (e-PCR)
- UniSTS:260729

RH94469 (e-PCR)
- UniSTS:119717

d3arb10 (e-PCR)
- UniSTS:121765

Cas1 (e-PCR), detects polymorphism
- UniSTS:141227

AW535533 (e-PCR)
- UniSTS:260853

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables aminoacylase activity	ISO Inferred from Sequence Orthology more info
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables catalase activity	IBA Inferred from Biological aspect of Ancestor more info
enables catalase activity	IDA Inferred from Direct Assay more info	PubMed
enables catalase activity	IEA Inferred from Electronic Annotation more info
enables catalase activity	ISO Inferred from Sequence Orthology more info
enables catalase activity	TAS Traceable Author Statement more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on peroxide as acceptor	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in UV protection	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification of hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemoglobin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in hydrogen peroxide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to L-ascorbic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to UV	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amitrole	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to auditory stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to inactivity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light intensity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to ozone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to phenylpropanoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin E	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
is_active_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: catalase

NP_036652.1

EC 1.11.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.