Arl2 ARF like GTPase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arl2provided by RGD
Official Full Name: ARF like GTPase 2provided by RGD
Primary source: RGD:69326
See related: EnsemblRapid:ENSRNOG00000021010 AllianceGenome:RGD:69326
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in acetylcholine transport. Located in mitochondrial intermembrane space. Orthologous to human ARL2 (ADP ribosylation factor like GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 125.1), Brain (RPKM 120.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (212863422..212875425, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (203434129..203446156, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (221504150..221516191, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that miR-15b may decrease mitochondrial integrity by targeting Arl2 in the heart.
Title: MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acetylcholine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in bicellular tight junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in centrosome cycle	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of protein location in nucleus	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location in nucleus	ISO Inferred from Sequence Orthology more info
involved_in maintenance of protein location in nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell-substrate adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of aerobic respiration	IEA Inferred from Electronic Annotation more info
involved_in regulation of aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in cilium	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 2

Names: ADP-ribosylation factor like GTPase 2; ADP-ribosylation factor-like 2; ADP-ribosylation-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031711.2 → NP_113899.2 ADP-ribosylation factor-like protein 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O08697

UniProtKB/TrEMBL

A6HZE7

Related

ENSRNOP00000076049.2, ENSRNOT00000093048.3

Conserved Domains (1) summary

cd04154
Location:3 → 175

Arl2; Arf-like 2 (Arl2) GTPase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

212863422..212875425 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230899.4 → XP_006230961.1 ADP-ribosylation factor-like protein 2 isoform X1

UniProtKB/Swiss-Prot

O08697

UniProtKB/TrEMBL

G3V8V0

Related

ENSRNOP00000028525.4, ENSRNOT00000028525.7

Conserved Domains (1) summary

cd04154
Location:3 → 201

Arl2; Arf-like 2 (Arl2) GTPase
XM_039089915.2 → XP_038945843.1 ADP-ribosylation factor-like protein 2 isoform X2

Conserved Domains (1) summary

cl38936
Location:3 → 94

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases