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    Icos inducible T-cell co-stimulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64545, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Icosprovided by RGD
    Official Full Name
    inducible T-cell co-stimulatorprovided by RGD
    Primary source
    RGD:620123
    See related
    EnsemblRapid:ENSRNOG00000046196 AllianceGenome:RGD:620123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ailim
    Summary
    Involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Predicted to be located in external side of plasma membrane. Used to study myocarditis. Biomarker of colitis and uveitis. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency 1; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 162.0), Spleen (RPKM 50.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Icos in Genome Data Viewer
    Location:
    9q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (69862042..69900864)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (62368075..62406900)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (67748157..67786808)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Cd28 molecule Neighboring gene cytotoxic T-lymphocyte-associated protein 4 Neighboring gene proteasome 20S subunit alpha 7, pseudogene 3 Neighboring gene uncharacterized LOC108351940

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inducible co-stimulator (ICOS) is upregulated in experimental autoimmune uveoretinitis. Xing L, et al. Graefes Arch Clin Exp Ophthalmol, 2006 Dec. PMID 16601981
    2. AILIM/ICOS: a novel lymphocyte adhesion molecule. Tamatani T, et al. Int Immunol, 2000 Jan. PMID 10607749
    3. Attenuation of experimental autoimmune myocarditis by blocking activated T cells through inducible costimulatory molecule pathway. Futamatsu H, et al. Cardiovasc Res, 2003 Jul 1. PMID 12829180
    4. Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis. Ishii K, et al. J Gastroenterol Hepatol, 2004 Feb. PMID 14731127
    5. Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade. Guillonneau C, et al. Transplantation, 2005 Aug 27. PMID 16220623

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the increased expression of ICOS/ICOS ligand in periapical lesions was associated with the inflammatory infiltration and alveolar bone destruction of apical periodontitis
      Title: Association between Increased Inducible Costimulator/Inducible Costimulator Ligand Expression with Bone Destruction in Apical Periodontitis.
    2. ICOS-targeted siRNA can effectively silence gene expression of ICOS, and provided satisfactory treatment efficacy for myocardial cell hypertrophy after infarction.
      Title: Effect of siRNA silencing of inducible co-stimulatory molecule on myocardial cell hypertrophy after cardiac infarction in rats.
    3. ICOS siRNA can protect brain tissues from ischemia injuries after cerebral infarction, improve limb movement and coordination, lower the mortality rate of rats, and inhibit T cell-induced cytokines
      Title: Effect of Inducible Co-Stimulatory Molecule siRNA in Cerebral Infarction Rat Models.
    4. our data highlight a key role for ICOS signaling in the generation of imbalanced production of IL-10 and IL-17 by Treg cells in a rat model of spondyloarthritis.
      Title: Increased production of interleukin-17 over interleukin-10 by treg cells implicates inducible costimulator molecule in experimental spondyloarthritis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell costimulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell costimulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in T cell tolerance induction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T cell tolerance induction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in T follicular helper cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inducible T-cell costimulator
    Names
    activation-inducible lymphocyte immunomediatory molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431817.1 → NP_001418746.1  inducible T-cell costimulator isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    2. NM_001431818.1 → NP_001418747.1  inducible T-cell costimulator isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q9R1T7, Q9WVR9
      UniProtKB/TrEMBL
      A0A0G2JZC0, A6IPD8

    3. NM_001431819.1 → NP_001418748.1  inducible T-cell costimulator isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    4. NM_022610.3 → NP_072132.1  inducible T-cell costimulator isoform 1 precursor

      See identical proteins and their annotated locations for NP_072132.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q9R1T7, Q9WVR9
      UniProtKB/TrEMBL
      A0A0G2JZC0, A6IPD8
      Related
      ENSRNOP00000064455.1, ENSRNOT00000071226.4
      Conserved Domains (1) summary
      pfam15910
      Location:23 → 135
      V-set_2; ICOS V-set domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      69862042..69900864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767136.4 → XP_008765358.1  inducible T-cell costimulator isoform X1

      See identical proteins and their annotated locations for XP_008765358.1

      UniProtKB/TrEMBL
      A0A8I5ZN49, A6IPD9
      Conserved Domains (1) summary
      pfam15910
      Location:23 → 135
      V-set_2; ICOS V-set domain

    2. XM_006245038.5 → XP_006245100.1  inducible T-cell costimulator isoform X2

      Conserved Domains (1) summary
      pfam15910
      Location:23 → 135
      V-set_2; ICOS V-set domain

    3. XM_039084171.1 → XP_038940099.1  inducible T-cell costimulator isoform X4

      Conserved Domains (1) summary
      cl11960
      Location:21 → 58
      Ig; Immunoglobulin domain

    4. XM_006245037.5 → XP_006245099.1  inducible T-cell costimulator isoform X1

      See identical proteins and their annotated locations for XP_006245099.1

      UniProtKB/TrEMBL
      A0A8I5ZN49, A6IPD9
      Related
      ENSRNOP00000079452.1, ENSRNOT00000119869.2
      Conserved Domains (1) summary
      pfam15910
      Location:23 → 135
      V-set_2; ICOS V-set domain

    5. XM_063267687.1 → XP_063123757.1  inducible T-cell costimulator isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1T7.1 GenPept UniProtKB/Swiss-Prot:Q9R1T7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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