Slc5a5 solute carrier family 5 member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc5a5provided by RGD
Official Full Name: solute carrier family 5 member 5provided by RGD
Primary source: RGD:69267
See related: EnsemblRapid:ENSRNOG00000018822 AllianceGenome:RGD:69267
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nis
Summary: Enables sodium:iodide symporter activity. Involved in iodide transmembrane transport and sodium ion transport. Is active in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 10.9), Lung (RPKM 1.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18580705..18590692)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18546709..18556698)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20297414..20307401)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural insights into the mechanism of the sodium/iodide symporter.
Title: Structural insights into the mechanism of the sodium/iodide symporter.
Transcription Factor CREB3L1 Regulates the Expression of the Sodium/Iodide Symporter (NIS) in Rat Thyroid Follicular Cells.
Title: Transcription Factor CREB3L1 Regulates the Expression of the Sodium/Iodide Symporter (NIS) in Rat Thyroid Follicular Cells.
TNFalpha-mediated activation of NF-kappaB downregulates sodium-iodide symporter expression in thyroid cells
Title: TNFα-mediated activation of NF-κB downregulates sodium-iodide symporter expression in thyroid cells.
relationship between the size of the goiter and NIS regulation
Title: Regulation of thyroid sodium-iodide symporter in different stages of goiter: Possible involvement of reactive oxygen species.
Nis expression is controlled by Txn/Ape1 through a TSH/selenium-dependent mechanism.
Title: Selenium Increases Thyroid-Stimulating Hormone-Induced Sodium/Iodide Symporter Expression Through Thioredoxin/Apurinic/Apyrimidinic Endonuclease 1-Dependent Regulation of Paired Box 8 Binding Activity.
excess iodide transcriptionally represses NIS gene expression through the impairment of Pax8 and p65 transcriptional activity.
Title: Excess iodide downregulates Na(+)/I(-) symporter gene transcription through activation of PI3K/Akt pathway.
Report sodium binding date for NIS, where transporter activity is electrogenic, with a 2:1 Na(+)/I(-) transport stoichiometry.
Title: Beyond non-integer Hill coefficients: A novel approach to analyzing binding data, applied to Na+-driven transporters.
Although the affinity of NIS for I- is low, it increases when Na+ is bound. NIS takes advantage of the extracellular Na+ concentration and the pronounced increase in its own affinity for I- and for the second Na+ elicited by binding of the first.
Title: Physiological sodium concentrations enhance the iodide affinity of the Na+/I- symporter.
It is feasible to use lentiviral vectors to deliver sodium iodide symporter (NIS) gene for the non-invasive monitoring of bone marrowderived mesenchymal stem cell transplantation and survival in the infarcted myocardium in vivo.
Title: Feasibility of lentiviral‑mediated sodium iodide symporter gene delivery for the efficient monitoring of bone marrow‑derived mesenchymal stem cell transplantation and survival.
AMPK activation significantly induces NIS protein degradation through a lysosome-mediated mechanism.
Title: AMP-activated protein kinase activation leads to lysome-mediated NA(+)/I(-)-symporter protein degradation in rat thyroid cells.

Submit: New GeneRIF Correction See all GeneRIFs (31)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables iodide transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables iodide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic anion:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sodium:iodide symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:iodide symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:iodide symporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:iodide symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to Thyroid stimulating hormone	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gonadotropin stimulus	ISO Inferred from Sequence Orthology more info
involved_in inorganic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in iodide transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iodide transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iodide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in iodide transport	IDA Inferred from Direct Assay more info	PubMed
involved_in iodide transport	IEA Inferred from Electronic Annotation more info
involved_in iodide transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone generation	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone generation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/iodide cotransporter

Names: Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na+/I- symporter; sodium/iodide symporter; solute carrier family 5 (sodium iodide symporter), member 5; solute carrier family 5 (sodium/iodide cotransporter), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_052983.2 → NP_443215.2 sodium/iodide cotransporter

Status: VALIDATED

Source sequence(s)

BF392663, JAXUCZ010000016, U60282

UniProtKB/Swiss-Prot

Q63008

UniProtKB/TrEMBL

F1LR66

Related

ENSRNOP00000025577.2, ENSRNOT00000025576.5

Conserved Domains (1) summary

cd11503
Location:15 → 549

SLC5sbd_NIS; Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain