Sptan1 spectrin, alpha, non-erythrocytic 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sptan1provided by RGD
Official Full Name: spectrin, alpha, non-erythrocytic 1provided by RGD
Primary source: RGD:621714
See related: EnsemblRapid:ENSRNOG00000015396 AllianceGenome:RGD:621714
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: A2a; IPF; Spna2
Summary: Enables spectrin binding activity. Predicted to be involved in actin cytoskeleton organization. Located in plasma membrane. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 11 and developmental and epileptic encephalopathy 5. Orthologous to human SPTAN1 (spectrin alpha, non-erythrocytic 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 1510.8), Lung (RPKM 1056.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 59

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (33639020..33703890)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (13241164..13306047)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (8534437..8599259)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of dorsomedial striatum adenosine 2A receptors in the loss of goal-directed behaviour.
Title: The role of dorsomedial striatum adenosine 2A receptors in the loss of goal-directed behaviour.
alphaII-spectrin controls calcium-regulated exocytosis in neuroendocrine chromaffin cells through neuronal Wiskott-Aldrich Syndrome protein interaction.
Title: αII-spectrin controls calcium-regulated exocytosis in neuroendocrine chromaffin cells through neuronal Wiskott-Aldrich Syndrome protein interaction.
alphaII spectrin has a role in critical aspects of dendritic and axonal development and synaptogenesis, and there is a dominant-negative mechanism of SPTAN1 mutations in epileptic encephalopathy
Title: Critical roles of αII spectrin in brain development and epileptic encephalopathy.
These findings reveal spectrin (alpha/beta) / ankyrin B cytoskeletal and signaling proteins as key regulators of T-type calcium channels expressed in the nervous system.
Title: T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.
The present study demonstrates the age-dependent intraneuronal presence of an alphaII-spectrin cleavage fragment in mammalian forebrain which is exacerbated in a transgenic model of AD.
Title: Age-related intraneuronal elevation of αII-spectrin breakdown product SBDP120 in rodent forebrain accelerates in 3×Tg-AD mice.
the embryonic mammalian heart expresses a significant amount of alpha II-spectrin with a reduced avidity for beta-spectrin and the ability to promote myocyte growth
Title: Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat.
Results indicate that the phosphorylation-dependent interaction between 14-3-3beta and alphaII spectrin acts as a switch between positive and negative regulation of neurite outgrowth stimulated by NCAM.
Title: Binding of alphaII spectrin to 14-3-3beta is involved in NCAM-dependent neurite outgrowth.
Upregulation of Dpysl2 and Spna2 expression in hypertrophic cells in the penumbra regions of cortex and striatum of stroke brain indicates an early neuronal defense mechanism involving active neuronal repair, regeneration and development.
Title: Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke.
PDE4D4 interacts with alpha II spectrin within this membrane domain.
Title: Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation.
support a critical role for the alphaII-spectrin-SH3i isoform of spectrin in intracellular targeting of connexin 43 to gap junctions
Title: Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF390992 (e-PCR)
- UniSTS:249627

RH133209 (e-PCR)
- UniSTS:216492

RH134500 (e-PCR)
- UniSTS:217780

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables spectrin binding	IDA Inferred from Direct Assay more info	PubMed
enables spectrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cuticular plate	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in fascia adherens	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in paranodal junction	ISO Inferred from Sequence Orthology more info
located_in paranode region of axon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of spectrin	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: spectrin alpha chain, non-erythrocytic 1

Names: a--fodrin; alpha II spectrin; alpha-fodrin; alpha-spectrin 2; brain alpha-spectrin; fodrin alpha chain; inhibitory protein factor; noerythroid alpha-spectrin 2; nonerythroid alpha-spectrin 2; spectrin alpha chain, brain; spectrin, non-erythroid alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_171983.3 → NP_741984.3 spectrin alpha chain, non-erythrocytic 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

O88663, P16086, P70477

UniProtKB/TrEMBL

A0A8L2QL19, A6JTU2

Related

ENSRNOP00000070932.2, ENSRNOT00000079640.3

Conserved Domains (5) summary

cd11808
Location:971 → 1023

SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin

cd00051
Location:2327 → 2395

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:679 → 890

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00435
Location:1658 → 1762

Spectrin; Spectrin repeat

pfam08726
Location:2402 → 2470

EFhand_Ca_insen; Ca2+ insensitive EF hand

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

33639020..33703890

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284505.1 → XP_063140575.1 spectrin alpha chain, non-erythrocytic 1 isoform X3

UniProtKB/TrEMBL

A0A0G2K1Y8

Related

ENSRNOP00000093423.2, ENSRNOT00000095331.2
XM_063284503.1 → XP_063140573.1 spectrin alpha chain, non-erythrocytic 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K1Y8
XM_063284507.1 → XP_063140577.1 spectrin alpha chain, non-erythrocytic 1 isoform X5

UniProtKB/TrEMBL

A0A8L2QL19
XM_063284504.1 → XP_063140574.1 spectrin alpha chain, non-erythrocytic 1 isoform X2

UniProtKB/TrEMBL

A0A0G2K1Y8
XM_063284508.1 → XP_063140578.1 spectrin alpha chain, non-erythrocytic 1 isoform X6

UniProtKB/TrEMBL

A0A8L2QL19

Related

ENSRNOP00000071811.2, ENSRNOT00000079108.3
XM_063284506.1 → XP_063140576.1 spectrin alpha chain, non-erythrocytic 1 isoform X4

UniProtKB/TrEMBL

A0A0G2JTH0
XM_063284509.1 → XP_063140579.1 spectrin alpha chain, non-erythrocytic 1 isoform X7

UniProtKB/TrEMBL

Q6IRK8
XM_063284510.1 → XP_063140580.1 spectrin alpha chain, non-erythrocytic 1 isoform X8

UniProtKB/TrEMBL

Q6IRK8
XM_063284511.1 → XP_063140581.1 spectrin alpha chain, non-erythrocytic 1 isoform X9

UniProtKB/TrEMBL

A0A0G2K1Y8

Related

ENSRNOP00000072038.1, ENSRNOT00000091697.3
XM_039105784.2 → XP_038961712.2 spectrin alpha chain, non-erythrocytic 1 isoform X11

UniProtKB/TrEMBL

A0A8L2QL19
XM_063284512.1 → XP_063140582.1 spectrin alpha chain, non-erythrocytic 1 isoform X12

UniProtKB/TrEMBL

A0A8L2QL19
XM_039105783.2 → XP_038961711.2 spectrin alpha chain, non-erythrocytic 1 isoform X10

UniProtKB/TrEMBL

A0A0G2JTH0

Related

ENSRNOP00000068710.2, ENSRNOT00000082672.3
XM_039105785.2 → XP_038961713.2 spectrin alpha chain, non-erythrocytic 1 isoform X13

UniProtKB/TrEMBL

Q6IRK8
XM_063284513.1 → XP_063140583.1 spectrin alpha chain, non-erythrocytic 1 isoform X14

UniProtKB/TrEMBL

Q6IRK8

Related

ENSRNOP00000042382.6, ENSRNOT00000045827.6