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    Trappc3 trafficking protein particle complex subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trappc3provided by RGD
    Official Full Name
    trafficking protein particle complex subunit 3provided by RGD
    Primary source
    RGD:1309135
    See related
    EnsemblRapid:ENSRNOG00000010550 AllianceGenome:RGD:1309135
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Predicted to be located in Golgi membrane. Predicted to be part of TRAPP complex. Predicted to be active in cis-Golgi network membrane and cytosol. Orthologous to human TRAPPC3 (trafficking protein particle complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 245.6), Kidney (RPKM 234.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trappc3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (143843612..143857347)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (138559238..138572825)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144281720..144295306)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103176 Neighboring gene MAP7 domain containing 1 Neighboring gene uncharacterized LOC134486990 Neighboring gene collagen type VIII alpha 2 chain Neighboring gene ADP-ribosylserine hydrolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus. Loh E, et al. J Cell Sci, 2005 Mar 15. PMID 15728249
    2. mBET3 is required for the organization of the TRAPP complexes. Menon S, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17027922
    3. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. Scrivens PJ, et al. Mol Biol Cell, 2011 Jun 15. PMID 21525244, Free PMC Article
    4. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus
      Title: Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105948

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cis-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 3
    Names
    BET3 homolog
    trafficking protein particle complex 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008376.1 → NP_001008377.1  trafficking protein particle complex subunit 3

      See identical proteins and their annotated locations for NP_001008377.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086377
      UniProtKB/Swiss-Prot
      Q5U1Z2
      UniProtKB/TrEMBL
      A0A8L2Q6T4, A6ISA1
      Related
      ENSRNOP00000014383.5, ENSRNOT00000014383.8
      Conserved Domains (1) summary
      cd14942
      Location:15 → 169
      TRAPPC3_bet3; Bet3-TRAPPC3 subunit of the TRAPP complex

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      143843612..143857347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288019.1 → XP_063144089.1  trafficking protein particle complex subunit 3 isoform X1

    2. XM_063288021.1 → XP_063144091.1  trafficking protein particle complex subunit 3 isoform X2

    3. XM_039110349.1 → XP_038966277.1  trafficking protein particle complex subunit 3 isoform X3

      Conserved Domains (1) summary
      cd14942
      Location:1 → 85
      TRAPPC3_bet3; Bet3-TRAPPC3 subunit of the TRAPP complex

    4. XM_063288020.1 → XP_063144090.1  trafficking protein particle complex subunit 3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U1Z2.1 GenPept UniProtKB/Swiss-Prot:Q5U1Z2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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