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    Gsta4 glutathione S-transferase alpha 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300850, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gsta4provided by RGD
    Official Full Name
    glutathione S-transferase alpha 4provided by RGD
    Primary source
    RGD:1309970
    See related
    EnsemblRapid:ENSRNOG00000030449 AllianceGenome:RGD:1309970
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables organic cyclic compound binding activity and toxic substance binding activity. Involved in several processes, including cellular response to lithium ion; response to herbicide; and response to zinc ion. Predicted to be located in cytosol. Orthologous to human GSTA4 (glutathione S-transferase alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 1098.2), Liver (RPKM 846.5) and 7 other tissues See more
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    Genomic context

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    See Gsta4 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (87947247..87964490)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (79066967..79084193)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (85497557..85514732)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ciliogenesis associated kinase 1 Neighboring gene ribosomal protein L12, pseudogene 1 Neighboring gene glutathione S-transferase alpha 5 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cytosolic glutathione transferases from rat liver. Primary structure of class alpha glutathione transferase 8-8 and characterization of low-abundance class Mu glutathione transferases. Alin P, et al. Biochem J, 1989 Jul 15. PMID 2775231, Free PMC Article
    2. Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain. Bhagwat SV, et al. Biochem Pharmacol, 1998 Oct 1. PMID 9774145
    3. Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats. Ahmad I, et al. Chem Biol Interact, 2013 Jan 25. PMID 23159886
    4. Naturally occurring genetic variability in expression of Gsta4 is associated with differential survival of axotomized rat motoneurons. Ström M, et al. Neuromolecular Med, 2012 Mar. PMID 22160604
    5. Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. Singhal NK, et al. J Pineal Res, 2011 Mar. PMID 20964710

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis.
      Title: Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis.
    2. The results demonstrate that CYP2E1 induces iNOS-independent free radical generation and subsequently modulates the Nrf2-dependent HO-1 and 4-HNE-mediated GST expression in maneb- and paraquat-treated PMNs.
      Title: CYP2E1-mediated oxidative stress regulates HO-1 and GST expression in maneb- and paraquat-treated rat polymorphonuclear leukocytes.
    3. These results showed and mapped naturally occurring genetic differences in the expression of Gsta4 associated both with a highly significant increase in the survival of axotomized motoneurons and with a trans-regulation of several molecular pathways.
      Title: Naturally occurring genetic variability in expression of Gsta4 is associated with differential survival of axotomized rat motoneurons.
    4. A novel haplotype variant in the rat Gsta4 gene leads to increased brain transcript levels in ethanol-preferring AA rats compared to nonpreferring ANA rats, and may contribute to the difference in lifespan between these rodent lines.
      Title: Glutathione-S-transferase expression in the brain: possible role in ethanol preference and longevity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic cyclic compound binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables toxic substance binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to lithium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to herbicide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nicotine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase alpha-4
    Names
    GST 8-8
    GST A4-4
    GST K
    GST Yk
    glutathione S-transferase A4
    glutathione S-transferase Yk
    glutathione transferase
    NP_001100310.1
    XP_063121254.1
    XP_063121255.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106840.1 → NP_001100310.1  glutathione S-transferase alpha-4

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/Swiss-Prot
      P14942
      UniProtKB/TrEMBL
      A6HBU1, A9UMW1, B6DYP9
      Related
      ENSRNOP00000075572.1, ENSRNOT00000090146.3
      Conserved Domains (2) summary
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cl00388
      Location:4 → 82
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      87947247..87964490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265184.1 → XP_063121254.1  glutathione S-transferase alpha-4 isoform X1

      UniProtKB/Swiss-Prot
      P14942
      UniProtKB/TrEMBL
      A6HBU1, A9UMW1, B6DYP9

    2. XM_063265185.1 → XP_063121255.1  glutathione S-transferase alpha-4 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14942.2 GenPept UniProtKB/Swiss-Prot:P14942

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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