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    Letmd1 LETM1 domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Letmd1provided by RGD
    Official Full Name
    LETM1 domain containing 1provided by RGD
    Primary source
    RGD:1596738
    See related
    EnsemblRapid:ENSRNOG00000029855 AllianceGenome:RGD:1596738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310591
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in several processes, including mitochondrion organization; positive regulation of cold-induced thermogenesis; and regulation of phagocytosis. Predicted to be located in mitochondrial inner membrane; nucleolus; and nucleoplasm. Predicted to be active in mitochondrion and nucleus. Orthologous to human LETMD1 (LETM1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 241.7), Thymus (RPKM 240.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Letmd1 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133461920..133476592)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131584241..131597797)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142106364..142119900)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene thiol methyltransferase 1A Neighboring gene uncharacterized LOC134479577 Neighboring gene HIG1 hypoxia inducible domain family, member 1C Neighboring gene solute carrier family 11 member 2 Neighboring gene uncharacterized LOC120093735 Neighboring gene cysteine and serine rich nuclear protein 2 Neighboring gene transcription factor CP2 Neighboring gene uncharacterized LOC120093736 Neighboring gene POU class 6 homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization. Ko J, et al. Oncogene, 2003 Jul 24. PMID 12879013
    2. Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status. Ha SA, et al. BMC Cancer, 2009 Feb 11. PMID 19208263, Free PMC Article
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188743

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    LETM1 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122781.3 → NP_001116253.3  LETM1 domain-containing protein 1

      See identical proteins and their annotated locations for NP_001116253.3

      Status: VALIDATED

      Source sequence(s)
      BC159426, BQ204198, CB778986, CO573012, DN933141
      UniProtKB/TrEMBL
      A6KCJ7, G3V996
      Related
      ENSRNOP00000039848.3, ENSRNOT00000042786.6
      Conserved Domains (1) summary
      pfam07766
      Location:79 → 345
      LETM1; LETM1-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      133461920..133476592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242354.5 → XP_006242416.1  LETM1 domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006242416.1

      UniProtKB/TrEMBL
      B0K026
      Related
      ENSRNOP00000075497.1, ENSRNOT00000088681.3
      Conserved Domains (1) summary
      pfam07766
      Location:80 → 337
      LETM1; LETM1-like protein

    2. XM_063264252.1 → XP_063120322.1  LETM1 domain-containing protein 1 isoform X3

    3. XM_063264251.1 → XP_063120321.1  LETM1 domain-containing protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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