F5 coagulation factor V [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: F5provided by RGD
Official Full Name: coagulation factor Vprovided by RGD
Primary source: RGD:1589758
See related: EnsemblRapid:ENSRNOG00000057855 AllianceGenome:RGD:1589758
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ac2-120
Summary: Predicted to enable copper ion binding activity. Involved in response to vitamin K. Located in extracellular space. Used to study membranoproliferative glomerulonephritis. Biomarker of hepatitis and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal disease; factor V deficiency; liver disease (multiple); and non-arteritic anterior ischemic optic neuropathy. Orthologous to human F5 (coagulation factor V). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 499.3), Kidney (RPKM 81.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q23

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (79046657..79116247)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (76513509..76583106)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (82479997..82535540)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report differential effects of TAK-442, a novel orally active direct factor Xa inhibitor, and ximelagatran, a thrombin inhibitor, on factor V-mediated feedback on coagulation cascade and bleeding.
Title: Differential effects of TAK-442, a novel orally active direct factor Xa inhibitor, and ximelagatran, a thrombin inhibitor, on factor V-mediated feedback on coagulation cascade and bleeding.
ECM components accumulation may progress in accordance with coagulation in the mesangial area through mesangial factor V expression
Title: Coagulation in the mesangial area promotes ECM accumulation through factor V expression in MsPGN in rats.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood circulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation, extrinsic pathway	TAS Traceable Author Statement more info	PubMed
involved_in response to vitamin K	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coagulation factor V

Names: coagulation factor V (proaccelerin, labile factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419051.1 → NP_001405980.1 coagulation factor V

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A0G2K3W2

Related

ENSRNOP00000072800.2, ENSRNOT00000080759.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

79046657..79116247

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001047878.1: Suppressed sequence

Description

NM_001047878.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.