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    mt-Nd1 NADH dehydrogenase 1, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 26193, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mt-Nd1provided by RGD
    Official Full Name
    NADH dehydrogenase 1, mitochondrialprovided by RGD
    Primary source
    RGD:620555
    See related
    AllianceGenome:RGD:620555
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus (strain: BN/SsNHsdMCW)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ND1
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to contribute to NADH dehydrogenase activity. Involved in several processes, including response to hydroperoxide; response to hypoxia; and response to xenobiotic stimulus. Located in dendrite and neuronal cell body. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including MELAS syndrome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Orthologous to human MT-ND1 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mt-Nd1 in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    RS_2023_06 latest, but not current mRatBN7.2 (GCF_015227675.2) MT (non-nuclear) NC_001665.2 (2740..3694)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) MT (non-nuclear) NC_001665.2 (2740..3694)

    Chromosome MT - NC_001665.2Genomic Context describing neighboring genes Neighboring gene l-rRNA Neighboring gene tRNA-Leu Neighboring gene tRNA-Ile Neighboring gene tRNA-Gln Neighboring gene tRNA-Met

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells. Rafikov R, et al. Redox Biol, 2015 Dec. PMID 26298201, Free PMC Article
    2. Mitochondrial polymorphisms in rat genetic models of hypertension. Kumarasamy S, et al. Mamm Genome, 2010 Jun. PMID 20443117, Free PMC Article
    3. Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. Jové M, et al. J Lipid Res, 2004 Jan. PMID 14563825
    4. Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells. Tendi EA, et al. Neurochem Res, 2002 Apr. PMID 11958534
    5. Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. Suliman HB, et al. Free Radic Biol Med, 2002 Feb 1. PMID 11827750

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Electron transport complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.
      Title: Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    • Nd1; NADH1

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hydroperoxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase subunit 1
    YP_665629.1
    • TAA stop codon is completed by the addition of 3' A residues to the mRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001665.2 Reference assembly

      Range
      2740..3694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_665629.1 NADH dehydrogenase subunit 1 (mitochondrion) [Rattus norvegicus]

      See identical proteins and their annotated locations for YP_665629.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O63197, P03889, Q37653
      UniProtKB/TrEMBL
      D2E6L7, H9KVF8, Q8HID1, Q8SEZ8
      Conserved Domains (1) summary
      MTH00104
      Location:1 → 318
      ND1; NADH dehydrogenase subunit 1; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03889.3

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