Tle4 TLE family member 4, transcriptional corepressor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tle4provided by RGD
Official Full Name: TLE family member 4, transcriptional corepressorprovided by RGD
Primary source: RGD:3868
See related: EnsemblRapid:ENSRNOG00000013239 AllianceGenome:RGD:3868
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Esp2; Grg-4
Summary: Predicted to enable DNA-binding transcription factor binding activity; chromatin binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in nucleus. Orthologous to human TLE4 (TLE family member 4, transcriptional corepressor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 120.1), Brain (RPKM 108.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (221086250..221222826, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (211661738..211798458, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (231394606..231531396, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sox10 Activity and the Timing of Schwann Cell Differentiation Are Controlled by a Tle4-Dependent Negative Feedback Loop.
Title: Sox10 Activity and the Timing of Schwann Cell Differentiation Are Controlled by a Tle4-Dependent Negative Feedback Loop.

Submit: New GeneRIF Correction

General gene information

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Markers

RH44484 (e-PCR)
- UniSTS:56323

BE118064 (e-PCR)
- UniSTS:248786

Tle4 (e-PCR), detects polymorphism
- UniSTS:527580

AA792082 (e-PCR)
- UniSTS:166128

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transducin-like enhancer protein 4

Names: groucho-related protein 4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 4, E(spl) homolog; transducin-like enhancer of split 4, homolog of Drosophila E(spl)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414041.1 → NP_001400970.1 transducin-like enhancer protein 4 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K7M5

Related

ENSRNOP00000074268.3, ENSRNOT00000087140.3
NM_019141.3 → NP_062014.2 transducin-like enhancer protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q07141

UniProtKB/TrEMBL

A6I0H0, F1LQJ5

Related

ENSRNOP00000018452.6, ENSRNOT00000018452.8

Conserved Domains (3) summary

cd00200
Location:462 → 746

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:466 → 505

7WD40; WD40 repeat [structural motif]

pfam03920
Location:16 → 103

TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

221086250..221222826 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760286.4 → XP_008758508.1 transducin-like enhancer protein 4 isoform X4

UniProtKB/Swiss-Prot

Q07141

Conserved Domains (3) summary

cd00200
Location:461 → 745

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:465 → 504

7WD40; WD40 repeat [structural motif]

pfam03920
Location:8 → 113

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006231128.5 → XP_006231190.1 transducin-like enhancer protein 4 isoform X1

UniProtKB/TrEMBL

A0A0G2K7M5, F1M0E7

Related

ENSRNOP00000018272.8, ENSRNOT00000018272.10

Conserved Domains (3) summary

cd00200
Location:487 → 771

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:491 → 530

7WD40; WD40 repeat [structural motif]

pfam03920
Location:16 → 139

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_039101907.2 → XP_038957835.1 transducin-like enhancer protein 4 isoform X2

UniProtKB/TrEMBL

A0A0G2K7M5, A0A8I6AEP9

Related

ENSRNOP00000092863.1, ENSRNOT00000119003.2

Conserved Domains (3) summary

cd00200
Location:485 → 769

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:489 → 528

7WD40; WD40 repeat [structural motif]

pfam03920
Location:14 → 137

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_039101922.2 → XP_038957850.1 transducin-like enhancer protein 4 isoform X6

UniProtKB/Swiss-Prot

Q07141

Conserved Domains (3) summary

cd00200
Location:459 → 743

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:463 → 502

7WD40; WD40 repeat [structural motif]

pfam03920
Location:14 → 107

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_039101920.2 → XP_038957848.1 transducin-like enhancer protein 4 isoform X5

UniProtKB/Swiss-Prot

Q07141

Conserved Domains (3) summary

cd00200
Location:460 → 744

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:464 → 503

7WD40; WD40 repeat [structural motif]

pfam03920
Location:14 → 101

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_039101913.2 → XP_038957841.1 transducin-like enhancer protein 4 isoform X3

UniProtKB/TrEMBL

A0A0G2K7M5

Conserved Domains (3) summary

cd00200
Location:484 → 768

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:488 → 527

7WD40; WD40 repeat [structural motif]

pfam03920
Location:14 → 136

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_039101927.2 → XP_038957855.1 transducin-like enhancer protein 4 isoform X7

UniProtKB/TrEMBL

A0A8I6AJ57

Conserved Domains (2) summary

cd00200
Location:289 → 573

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:293 → 332

7WD40; WD40 repeat [structural motif]