Ptprq protein tyrosine phosphatase, receptor type, Q [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprqprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Qprovided by RGD
Primary source: RGD:620779
See related: EnsemblRapid:ENSRNOG00000056915 AllianceGenome:RGD:620779
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rPTP-GMC1
Summary: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound and regulation of fat cell differentiation. Predicted to act upstream of or within hematopoietic progenitor cell differentiation; neuromuscular process controlling balance; and vestibular receptor cell morphogenesis. Predicted to be located in apical plasma membrane and stereocilium base. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 73 and autosomal recessive nonsyndromic deafness 84A. Orthologous to human PTPRQ (protein tyrosine phosphatase receptor type Q). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 9.9), Kidney (RPKM 2.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 7q21

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (44720916..44903291, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (42834455..43016807, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (49763657..50034932, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTPRQ represents a subtype of the PTPases whose biological activities result from its PIPase activity rather than its PTPase activity
Title: Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142218 (e-PCR)
- UniSTS:231468

Ptprq (e-PCR), detects polymorphism
- UniSTS:144304

Ptprq (e-PCR), detects polymorphism
- UniSTS:547527

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus involved in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of mechanical stimulus involved in sensory perception of sound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in vestibular receptor cell morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vestibular receptor cell morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium base	IEA Inferred from Electronic Annotation more info
located_in stereocilium base	ISO Inferred from Sequence Orthology more info
located_in stereocilium base	ISS Inferred from Sequence or Structural Similarity more info
located_in stereocilium bundle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol phosphatase PTPRQ

Names: PTP-RQ; R-PTP-Q; glomerular mesangial cell receptor protein-tyrosine phosphatase; phosphotidylinositol phosphatase PTPRQ; protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1; receptor-type tyrosine-protein phosphatase Q

NP_075214.2

EC 3.1.3.36

EC 3.1.3.48

EC 3.1.3.67

EC 3.1.3.86

EC 3.1.3.95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022925.2 → NP_075214.2 phosphatidylinositol phosphatase PTPRQ precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O88488

UniProtKB/TrEMBL

A0A0G2JUZ7, A6IGD1

Related

ENSRNOP00000069293.2, ENSRNOT00000081885.3

Conserved Domains (5) summary

cd00063
Location:58 → 152

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl06408
Location:1760 → 1929

UP_III_II; Uroplakin IIIb, IIIa and II

cd14616
Location:2034 → 2257

R-PTPc-Q; catalytic domain of receptor-type tyrosine-protein phosphatase Q

pfam00041
Location:669 → 748

fn3; Fibronectin type III domain

cl21522
Location:400 → 442

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

44720916..44903291 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_198323.1: Suppressed sequence

Description

NM_198323.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.