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    Dut deoxyuridine triphosphatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dutprovided by RGD
    Official Full Name
    deoxyuridine triphosphataseprovided by RGD
    Primary source
    RGD:620849
    See related
    EnsemblRapid:ENSRNOG00000007221 AllianceGenome:RGD:620849
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dutp; PIP4
    Summary
    Enables several functions, including dUTP diphosphatase activity; peroxisome proliferator activated receptor binding activity; and pyrimidine deoxyribonucleotide binding activity. Involved in several processes, including liver development; pyrimidine deoxyribonucleotide metabolic process; and regulation of protein-containing complex assembly. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DUT (deoxyuridine triphosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 344.2), Thymus (RPKM 330.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dut in Genome Data Viewer
    Location:
    3q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (132952258..132963433)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (112498864..112509994)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (117514399..117525450)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 1 Neighboring gene ribosomal protein L32, pseudogene 1 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene fibrillin 1 Neighboring gene uncharacterized LOC120101649

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of candidate growth-regulating genes that are overexpressed in late gestation fetal liver in the rat. Gruppuso PA, et al. Biochim Biophys Acta, 2000 Dec 1. PMID 11121581
    2. Purification and characterization of deoxyuridine triphosphate nucleotidohydrolase from anemic rat spleen: a trimer composition of the enzyme protein. Hokari S, et al. Arch Biochem Biophys, 1987 Mar. PMID 3032103
    3. Deoxyuridine triphosphate nucleotidohydrolase activity and its correlation with multiplication of erythroid cells in rat spleen. Hokari S, et al. Biochem Int, 1987 May. PMID 2841940
    4. dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure. Dos Santos RS, et al. Diabetes, 2017 Apr. PMID 28073829
    5. Immunohistochemical detection of dUTPase in intracranial tumors. Romeike BF, et al. Pathol Res Pract, 2005. PMID 16325515

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DUT inhibition by two independent siRNAs increased apoptosis in beta-cells.
      Title: dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dUTP diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dUTP diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dUTP diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxisome proliferator activated receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyrimidine deoxyribonucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dTMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dUMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dUMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dUTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUTP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    deoxyuridine 5'-triphosphate nucleotidohydrolase
    Names
    PPAR-interacting protein 4
    dUTP pyrophosphatase
    dUTPase
    NP_001035361.1
    NP_446044.1
    XP_008760410.1
    XP_038961577.1
    XP_038961579.1
    XP_063140395.1
    XP_063140396.1
    XP_063140397.1
    XP_063140398.1
    XP_063140399.1
    XP_063140400.1
    XP_063140401.1
    XP_063140402.1
    XP_063140403.1
    XP_063140404.1
    XP_063140405.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040271.2 → NP_001035361.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2

      See identical proteins and their annotated locations for NP_001035361.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' CDS compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HPW6
      Conserved Domains (1) summary
      cl00493
      Location:2 → 159
      trimeric_dUTPase; Trimeric dUTP diphosphatases

    2. NM_053592.3 → NP_446044.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 1

      See identical proteins and their annotated locations for NP_446044.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P70583
      UniProtKB/TrEMBL
      A6HPW5
      Related
      ENSRNOP00000009549.1, ENSRNOT00000009549.4
      Conserved Domains (1) summary
      cl00493
      Location:51 → 203
      trimeric_dUTPase; Trimeric dUTP diphosphatases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      132952258..132963433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762188.3 → XP_008760410.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X7

      Conserved Domains (1) summary
      cl00493
      Location:66 → 163
      trimeric_dUTPase; Trimeric dUTP diphosphatases

    2. XM_063284332.1 → XP_063140402.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X9

    3. XM_063284327.1 → XP_063140397.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X3

    4. XM_063284331.1 → XP_063140401.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X8

    5. XM_063284326.1 → XP_063140396.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X2

    6. XM_063284329.1 → XP_063140399.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X5

      Related
      ENSRNOP00000112289.1, ENSRNOT00000137124.1

    7. XM_063284330.1 → XP_063140400.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X6

    8. XM_063284333.1 → XP_063140403.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X10

    9. XM_063284334.1 → XP_063140404.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X11

    10. XM_063284325.1 → XP_063140395.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X1

    11. XM_063284328.1 → XP_063140398.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X4

    12. XM_063284335.1 → XP_063140405.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X12

    13. XM_039105649.2 → XP_038961577.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X12

      Conserved Domains (1) summary
      cl00493
      Location:18 → 110
      trimeric_dUTPase; Trimeric dUTP diphosphatases

    14. XM_039105651.2 → XP_038961579.1  deoxyuridine 5'-triphosphate nucleotidohydrolase isoform X13

      Conserved Domains (1) summary
      cl00493
      Location:42 → 109
      trimeric_dUTPase; Trimeric dUTP diphosphatases

    RNA

    1. XR_010064679.1 RNA Sequence

    2. XR_010064680.1 RNA Sequence

    3. XR_010064681.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70583.3 GenPept UniProtKB/Swiss-Prot:P70583

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