Vipr1 vasoactive intestinal peptide receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vipr1provided by RGD
Official Full Name: vasoactive intestinal peptide receptor 1provided by RGD
Primary source: RGD:3961
See related: EnsemblRapid:ENSRNOG00000047457 AllianceGenome:RGD:3961
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: VASREC; VIP-R-1; PACAP-R2; PACAP-R-2; RATVASREC; RGD1564352
Summary: Enables vasoactive intestinal polypeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in achalasia. Orthologous to human VIPR1 (vasoactive intestinal peptide receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 634.1) and Liver (RPKM 101.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (130181219..130217098)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (121303739..121339587)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (130283453..130313431)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
Title: PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.
Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats.
Title: Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats.
the protein and mRNA expression of pituitary adenylate cyclase-activating polypeptide-related receptors (PAC1, VPAC1, and VPAC2) in the trigeminal ganglia and trigeminal nucleus caudalis to identify changes associated with repetitive applications of chemical dural stimulations.
Title: Chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulation in rats.
Stimulating hippocampal microglia with the peptide neurotransmitter VIP via VPAC1 receptors increases production of IL-4 which promotes their trophic and proliferative effects on neural stem/progenitor cells
Title: Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release.
In cultured rat conjunctival goblet cells, VPAC1 and 2 receptors are functional; VIP stimulates a cAMP-dependent increase in [Ca(2+)]i and glycoconjugate secretion, but not ERK1/2 activation.
Title: Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells.
both VPAC1 and VPAC2 could have roles at all stages of retinal development, that PACAP acts through a specific set of PAC1 isoforms, and that Hip and Hop1 are predominantly involved in the postnatal development of rat retina.
Title: Development-related splicing regulates pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the retina.
investigation of role of VPAC1 (& VPAC2) in pulmonary circulation in health/disease: distribution of VPAC1 (& VPAC2) in pulmonary artery & aorta (& smooth muscle cells from these vessels); effects of VPAC antagonists on cell proliferation
Title: Role of VPAC1 and VPAC2 in VIP mediated inhibition of rat pulmonary artery and aortic smooth muscle cell proliferation.
Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats.
Title: Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats.
characterization of this receptor in cultured rat penis corpus cavernosum smooth muscle cells and its interaction with guanylate cyclase-B receptors
Title: Characterization of VIP and PACAP receptors in cultured rat penis corpus cavernosum smooth muscle cells and their interaction with guanylate cyclase-B receptors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129450 (e-PCR)
- UniSTS:212756

AV071699 (e-PCR)
- UniSTS:165672

MARC_17029-17030:1023294211:1 (e-PCR)
- UniSTS:268190

MARC_17029-17030:1032554955:3 (e-PCR)
- UniSTS:268190

Vipr1 (e-PCR), detects polymorphism
- UniSTS:546542

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables pituitary adenylate cyclase-activating polypeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables vasoactive intestinal polypeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasoactive intestinal polypeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables vasoactive intestinal polypeptide receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vasoactive intestinal polypeptide receptor 1

Names: PACAP type II receptor; pituitary adenylate cyclase-activating polypeptide type II receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012685.2 → NP_036817.1 vasoactive intestinal polypeptide receptor 1 precursor

See identical proteins and their annotated locations for NP_036817.1

Status: PROVISIONAL

Source sequence(s)

BC087136

UniProtKB/Swiss-Prot

P30083

UniProtKB/TrEMBL

A6I446

Related

ENSRNOP00000065438.3, ENSRNOT00000071573.4

Conserved Domains (2) summary

smart00008
Location:59 → 130

HormR; Domain present in hormone receptors

cd15269
Location:140 → 407

7tmB1_VIP-R1; vasoactive intestinal polypeptide (VIP) receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

130181219..130217098

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080845.2 → XP_038936773.1 vasoactive intestinal polypeptide receptor 1 isoform X2

Conserved Domains (2) summary

smart00008
Location:59 → 130

HormR; Domain present in hormone receptors

cd15269
Location:139 → 406

7tmB1_VIP-R1; vasoactive intestinal polypeptide (VIP) receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors
XM_039080844.2 → XP_038936772.1 vasoactive intestinal polypeptide receptor 1 isoform X1

UniProtKB/Swiss-Prot

P30083

UniProtKB/TrEMBL

A6I446

Conserved Domains (2) summary

smart00008
Location:59 → 130

HormR; Domain present in hormone receptors

cd15269
Location:140 → 407

7tmB1_VIP-R1; vasoactive intestinal polypeptide (VIP) receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors