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    Chadl chondroadherin-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100910434, updated on 9-Dec-2024

    Summary

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    Symbol
    Chadlprovided by RGD
    Full Name
    chondroadherin-likeprovided by RGD
    Primary source
    RGD:6504353
    See related
    EnsemblRapid:ENSRNOG00000024631 AllianceGenome:RGD:6504353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable collagen binding activity and collagen fibril binding activity. Predicted to be involved in negative regulation of chondrocyte differentiation and negative regulation of collagen fibril organization. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in external side of plasma membrane; extracellular matrix; and extracellular space. Orthologous to human CHADL (chondroadherin like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 14.6), Lung (RPKM 13.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chadl in Genome Data Viewer
    Location:
    7q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115085447..115097565, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113205323..113218678, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122915847..122929127, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene E1A binding protein p300 Neighboring gene ribosomal protein L35A like 1 Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene uncharacterized LOC120093698 Neighboring gene RAN GTPase activating protein 1 Neighboring gene zinc finger CCCH-type containing 7B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation. Tillgren V, et al. J Biol Chem, 2015 Jan 9. PMID 25451920, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables collagen fibril binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chondroadherin-like; chondroadherin-like protein
    Names
    chondroadherin-like protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432133.1 → NP_001419062.1  chondroadherin-like precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HT11, F1LVK3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      115085447..115097565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264686.1 → XP_063120756.1  chondroadherin-like protein isoform X2

      UniProtKB/TrEMBL
      A6HT11
      Related
      ENSRNOP00000102525.1, ENSRNOT00000125706.1

    2. XM_063264685.1 → XP_063120755.1  chondroadherin-like protein isoform X1

    3. XM_063264684.1 → XP_063120754.1  chondroadherin-like protein isoform X1

      UniProtKB/TrEMBL
      A6HT11, F1LVK3

    4. XM_008765809.4 → XP_008764031.1  chondroadherin-like protein isoform X1

      See identical proteins and their annotated locations for XP_008764031.1

      UniProtKB/TrEMBL
      A6HT11, F1LVK3
      Related
      ENSRNOP00000000205.6, ENSRNOT00000000205.8
      Conserved Domains (6) summary
      smart00013
      Location:27 → 59
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:663 → 711
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:381 → 617
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:656 → 667
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:58 → 81
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:437 → 497
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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