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    Chst8 carbohydrate sulfotransferase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308511, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Chst8provided by RGD
    Official Full Name
    carbohydrate sulfotransferase 8provided by RGD
    Primary source
    RGD:1308979
    See related
    EnsemblRapid:ENSRNOG00000070506 AllianceGenome:RGD:1308979
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N-acetylgalactosamine 4-O-sulfotransferase activity. Predicted to be involved in hormone biosynthetic process and sulfur compound metabolic process. Predicted to act upstream of or within proteoglycan biosynthetic process. Orthologous to human CHST8 (carbohydrate sulfotransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 16.9), Kidney (RPKM 4.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chst8 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (96431144..96572880, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (87294144..87435900, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (90542095..90685257, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100910905 Neighboring gene potassium channel tetramerization domain containing 15 Neighboring gene uncharacterized LOC108349467 Neighboring gene uncharacterized LOC134483097 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 like 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene peptidase D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of GalNAc 4-sulfotransferase expressed in human pituitary gland. Okuda T, et al. J Biol Chem, 2000 Dec 22. PMID 11001942
    2. Mouse N-acetylgalactosamine 4-sulfotransferases-1 and -2. Molecular cloning, expression, chromosomal mapping and detection of their activity with GalNAcbeta1-4GlcNAcbeta1-octyl. Okuda T, et al. J Biochem, 2003 Jul. PMID 12944377
    3. Molecular cloning and expression of the pituitary glycoprotein hormone N-acetylgalactosamine-4-O-sulfotransferase. Xia G, et al. J Biol Chem, 2000 Dec 8. PMID 10988300
    4. Molecular cloning and expression of two distinct human N-acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc beta 1-->4GlcNAc beta 1-->R in both N- and O-glycans. Hiraoka N, et al. Glycobiology, 2001 Jun. PMID 11445554
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dermatan 4-sulfotransferase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in hormone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 8
    Names
    carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
    NP_001100974.1
    XP_063117731.1
    XP_063117732.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107504.2 → NP_001100974.1  carbohydrate sulfotransferase 8

      See identical proteins and their annotated locations for NP_001100974.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161905
      UniProtKB/TrEMBL
      B1WBV7
      Related
      ENSRNOP00000107768.1, ENSRNOT00000156329.1
      Conserved Domains (1) summary
      pfam03567
      Location:180 → 409
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      96431144..96572880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261662.1 → XP_063117732.1  carbohydrate sulfotransferase 8 isoform X1

      UniProtKB/TrEMBL
      B1WBV7

    2. XM_063261661.1 → XP_063117731.1  carbohydrate sulfotransferase 8 isoform X1

      UniProtKB/TrEMBL
      B1WBV7
    Nucleotide Protein Strain
    Heading Accession and Version

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