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    Ngfr nerve growth factor receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24596, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ngfrprovided by RGD
    Official Full Name
    nerve growth factor receptorprovided by RGD
    Primary source
    RGD:3177
    See related
    EnsemblRapid:ENSRNOG00000005392 AllianceGenome:RGD:3177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p75; LNGFR; p75NTR; RNNGFRR; Tnfrsf16
    Summary
    Enables several functions, including amyloid-beta binding activity; nerve growth factor binding activity; and neurotrophin TRKA receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and regulation of neuron projection development. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and perikaryon. Is active in neuromuscular junction and presynaptic membrane. Used to study degenerative disc disease; glaucoma; hypertension; and middle cerebral artery infarction. Biomarker of several diseases, including alcohol dependence; brain disease (multiple); neuropathy (multiple); polycystic ovary syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease and depressive disorder. Orthologous to human NGFR (nerve growth factor receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 29.6), Adrenal (RPKM 23.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ngfr in Genome Data Viewer
    Location:
    10q26
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81012077..81030305, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (80515287..80533518, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (83389828..83408061, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA4 Neighboring gene speckle type BTB/POZ protein Neighboring gene neurexophilin 3 Neighboring gene uncharacterized LOC120095179 Neighboring gene prohibitin 1 Neighboring gene zinc finger protein 652

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amyloid-beta binding PubMed 
    enables calmodulin binding  
    enables calmodulin binding  
    enables calmodulin binding  
    enables coreceptor activity  
    enables coreceptor activity  
    enables coreceptor activity  
    enables death receptor activity  
    enables death receptor activity  
    enables death receptor activity  
    enables identical protein binding PubMed 
    enables nerve growth factor binding  
    enables nerve growth factor binding PubMed 
    enables nerve growth factor binding  
    enables nerve growth factor binding  
    enables neurotrophin TRKA receptor binding PubMed 
    enables neurotrophin binding PubMed 
    enables preprotein binding PubMed 
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables small GTPase binding  
    enables small GTPase binding  
    enables small GTPase binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 87
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction  
    involved_in Rho protein signal transduction  
    involved_in Rho protein signal transduction  
    involved_in apoptotic process  
    involved_in axon guidance  
    acts_upstream_of_or_within axon guidance  
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to oxidative stress PubMed 
    involved_in central nervous system development  
    acts_upstream_of_or_within central nervous system development  
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    involved_in circadian rhythm  
    involved_in detection of temperature stimulus  
    acts_upstream_of_or_within detection of temperature stimulus  
    involved_in dorsal aorta development  
    involved_in dorsal aorta development  
    involved_in extrinsic apoptotic signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    acts_upstream_of fibroblast growth factor receptor signaling pathway  
    involved_in fibroblast proliferation  
    acts_upstream_of fibroblast proliferation  
    involved_in glucose homeostasis  
    involved_in glucose homeostasis  
    acts_upstream_of hair follicle development  
    involved_in hair follicle morphogenesis  
    acts_upstream_of_or_within hair follicle morphogenesis  
    involved_in intracellular glucose homeostasis  
    involved_in intracellular glucose homeostasis  
    involved_in intracellular glucose homeostasis  
    involved_in intracellular protein transport  
    involved_in intracellular protein transport  
    involved_in intracellular protein transport  
    involved_in negative regulation of angiogenesis PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
    involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of dendritic spine development PubMed 
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway  
    acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway  
    involved_in negative regulation of hair follicle development  
    acts_upstream_of_or_within negative regulation of hair follicle development  
    involved_in negative regulation of mitochondrial depolarization PubMed 
    involved_in negative regulation of neuron apoptotic process PubMed 
    involved_in negative regulation of neuron projection development PubMed 
    involved_in nerve development  
    acts_upstream_of_or_within nerve development  
    involved_in neuron apoptotic process  
    involved_in neuron apoptotic process  
    involved_in odontogenesis of dentin-containing tooth  
    acts_upstream_of odontogenesis of dentin-containing tooth  
    involved_in positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of Rho protein signal transduction PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic signaling pathway  
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway  
    involved_in positive regulation of endothelial cell apoptotic process  
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of fibroblast proliferation  
    acts_upstream_of_or_within positive regulation of fibroblast proliferation  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of myelination PubMed 
    involved_in positive regulation of neural precursor cell proliferation PubMed 
    involved_in positive regulation of neuron differentiation PubMed 
    involved_in positive regulation of neuron projection development PubMed 
    involved_in positive regulation of odontogenesis of dentin-containing tooth  
    acts_upstream_of_or_within positive regulation of odontogenesis of dentin-containing tooth  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of synaptic transmission, cholinergic PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in presynaptic modulation of chemical synaptic transmission  
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of reactive oxygen species metabolic process PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in signal transduction  
    involved_in skeletal muscle cell differentiation PubMed 
    acts_upstream_of_or_within skin development  
    involved_in spermatogenesis PubMed 
    Items 1 - 25 of 87
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    is_active_in cell surface  
    located_in cell surface  
    located_in cell surface  
    located_in cell-cell junction  
    located_in cell-cell junction  
    located_in clathrin-coated endocytic vesicle PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in dendrite membrane PubMed 
    located_in dendritic spine  
    located_in external side of plasma membrane PubMed 
    located_in growth cone  
    located_in mitochondrion PubMed 
    is_active_in neuromuscular junction PubMed 
    located_in neuromuscular junction  
    is_active_in neuromuscular junction  
    located_in neuronal cell body membrane PubMed 
    located_in nuclear envelope PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in perikaryon PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic density  
    located_in postsynaptic density  
    located_in presynapse  
    is_active_in presynaptic membrane PubMed 
    Items 1 - 20 of 29

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 16
    Names
    NGF receptor
    gp80-LNGFR
    low affinity nerve growth factor receptor
    low affinity neurotrophin receptor p75NTR
    low-affinity nerve growth factor receptor p75NGFR
    low-affinity nerve growth factor receptor p75NGR
    nerve growth factor receptor (TNFR superfamily, member 16)
    nerve growth factor receptor, fast
    p75 ICD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012610.2NP_036742.2  tumor necrosis factor receptor superfamily member 16 precursor

      See identical proteins and their annotated locations for NP_036742.2

      Status: VALIDATED

      Source sequence(s)
      CB725789, JAXUCZ010000010, X05137
      UniProtKB/Swiss-Prot
      P07174
      UniProtKB/TrEMBL
      A6HIA5, G3V6P1
      Related
      ENSRNOP00000007268.1, ENSRNOT00000007268.5
      Conserved Domains (2) summary
      cd08311
      Location:341416
      Death_p75NR; Death domain of p75 Neurotrophin Receptor
      cd13416
      Location:31189
      TNFRSF16; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      81012077..81030305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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