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    Myo5a myosin VA [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25017, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myo5aprovided by RGD
    Official Full Name
    myosin VAprovided by RGD
    Primary source
    RGD:3143
    See related
    EnsemblRapid:ENSRNOG00000058866 AllianceGenome:RGD:3143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dop; Myh12
    Summary
    Enables several functions, including ATP binding activity; ATP-dependent protein binding activity; and syntaxin-1 binding activity. Involved in several processes, including cytoskeleton-dependent intracellular transport; positive regulation of cytochrome-c oxidase activity; and regulation of secretion by cell. Acts upstream of or within pigmentation. Located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Part of actomyosin, myosin complex part and ribonucleoprotein complex. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic actin cytoskeleton. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 616.0), Spleen (RPKM 175.8) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Myo5a in Genome Data Viewer
    Location:
    8q24
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (84692524..84860564)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (75811985..75980049)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (82038966..82156507)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene atos homolog A Neighboring gene cAMP-regulated phosphoprotein 19 Neighboring gene small nucleolar RNA U3 Neighboring gene myosin VC Neighboring gene G protein subunit beta 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding PubMed 
    enables ATP binding  
    enables ATP-dependent protein binding PubMed 
    enables SNARE binding PubMed 
    enables actin binding  
    enables actin binding  
    enables actin filament binding  
    enables calcium ion binding  
    enables calcium-dependent protein binding PubMed 
    enables calmodulin binding  
    enables cytoskeletal motor activity  
    enables cytoskeletal motor activity PubMed 
    enables cytoskeletal motor activity  
    enables disordered domain specific binding  
    enables identical protein binding  
    enables microfilament motor activity  
    enables microfilament motor activity PubMed 
    enables microfilament motor activity  
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables protein-containing complex binding PubMed 
    enables small GTPase binding  
    enables small GTPase binding  
    enables syntaxin-1 binding PubMed 
    Items 1 - 25 of 55
    Process Evidence Code Pubs
    involved_in actin filament organization  
    involved_in actin filament-based movement PubMed 
    acts_upstream_of_or_within actin filament-based movement  
    involved_in axo-dendritic protein transport PubMed 
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to insulin stimulus  
    acts_upstream_of_or_within chemical synaptic transmission  
    acts_upstream_of_or_within developmental pigmentation  
    involved_in dopamine metabolic process PubMed 
    involved_in endocytosis  
    acts_upstream_of_or_within endoplasmic reticulum localization  
    involved_in establishment of endoplasmic reticulum localization to postsynapse  
    acts_upstream_of_or_within exocytosis  
    acts_upstream_of_or_within hair follicle maturation  
    acts_upstream_of_or_within insulin secretion  
    acts_upstream_of_or_within locomotion involved in locomotory behavior  
    acts_upstream_of_or_within long-chain fatty acid biosynthetic process  
    involved_in macroautophagy PubMed 
    acts_upstream_of_or_within melanin biosynthetic process  
    acts_upstream_of_or_within melanin metabolic process  
    acts_upstream_of_or_within melanocyte differentiation  
    acts_upstream_of_or_within melanosome localization  
    acts_upstream_of_or_within melanosome transport  
    acts_upstream_of_or_within myelination  
    involved_in negative regulation of dopamine secretion PubMed 
    involved_in negative regulation of synaptic transmission, glutamatergic PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance  
    acts_upstream_of_or_within odontogenesis  
    acts_upstream_of_or_within pigmentation PubMed 
    acts_upstream_of_or_within pigmentation  
    involved_in positive regulation of cellular response to insulin stimulus PubMed 
    involved_in positive regulation of cytochrome-c oxidase activity PubMed 
    involved_in positive regulation of protein localization to plasma membrane PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell migration PubMed 
    involved_in post-Golgi vesicle-mediated transport  
    involved_in post-Golgi vesicle-mediated transport  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in protein transport  
    involved_in protein-containing complex assembly PubMed 
    involved_in reactive gliosis PubMed 
    NOT involved_in regulation of Golgi organization  
    involved_in regulation of exocytosis PubMed 
    acts_upstream_of_or_within regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity  
    involved_in regulation of postsynaptic cytosolic calcium ion concentration  
    involved_in secretory granule localization PubMed 
    involved_in secretory granule localization PubMed 
    acts_upstream_of_or_within secretory granule localization  
    acts_upstream_of_or_within synapse organization  
    involved_in vesicle transport along actin filament  
    involved_in vesicle transport along actin filament PubMed 
    involved_in vesicle transport along actin filament  
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport  
    acts_upstream_of_or_within visual perception  
    Items 1 - 25 of 55
    Items 1 - 20 of 59
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in actin cytoskeleton  
    located_in actin filament  
    located_in actin filament  
    located_in actomyosin  
    part_of actomyosin, myosin complex part PubMed 
    located_in axon PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in early endosome  
    located_in early endosome  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in filopodium tip  
    located_in filopodium tip  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in insulin-responsive compartment  
    located_in insulin-responsive compartment  
    located_in intermediate filament  
    located_in late endosome  
    located_in late endosome  
    located_in lysosome  
    located_in lysosome  
    located_in melanosome  
    located_in melanosome  
    is_active_in membrane  
    located_in membrane  
    located_in membrane  
    part_of myosin complex  
    part_of myosin complex  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    located_in peroxisome  
    located_in peroxisome  
    located_in photoreceptor outer segment  
    is_active_in postsynapse PubMed 
    is_active_in postsynapse PubMed 
    is_active_in postsynapse  
    is_active_in postsynaptic actin cytoskeleton PubMed 
    is_active_in postsynaptic actin cytoskeleton PubMed 
    located_in recycling endosome PubMed 
    located_in recycling endosome  
    located_in recycling endosome  
    part_of ribonucleoprotein complex PubMed 
    located_in ruffle  
    located_in ruffle  
    located_in secretory granule PubMed 
    located_in secretory granule  
    is_active_in smooth endoplasmic reticulum  
    located_in synaptic vesicle PubMed 
    part_of unconventional myosin complex  
    located_in vesicle  
    Items 1 - 20 of 59

    General protein information

    Preferred Names
    unconventional myosin-Va
    Names
    dilute myosin heavy chain, non-muscle
    dilute-opisthotonus
    myosin 5a
    myosin-Va

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022178.2NP_071514.2  unconventional myosin-Va

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K9X3
      Related
      ENSRNOP00000075108.3, ENSRNOT00000091789.3
      Conserved Domains (4) summary
      COG1196
      Location:11571417
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:71275
      COG5022; Myosin heavy chain [General function prediction only]
      cd15478
      Location:14541828
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83751
      MYSc_Myo5; class V myosin, motor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      84692524..84860564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080847.2XP_038936775.1  unconventional myosin-Va isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZJ51, A0A8I6A732
      Related
      ENSRNOP00000076388.1, ENSRNOT00000109142.2
      Conserved Domains (3) summary
      COG5022
      Location:71445
      COG5022; Myosin heavy chain [General function prediction only]
      cd15478
      Location:15031877
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83751
      MYSc_Myo5; class V myosin, motor domain
    2. XM_039080851.2XP_038936779.1  unconventional myosin-Va isoform X2

      UniProtKB/TrEMBL
      A0A8I6A732
      Conserved Domains (4) summary
      COG1196
      Location:11571441
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:71291
      COG5022; Myosin heavy chain [General function prediction only]
      cd15478
      Location:14781852
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83751
      MYSc_Myo5; class V myosin, motor domain
    3. XM_039080852.2XP_038936780.1  unconventional myosin-Va isoform X3

      UniProtKB/TrEMBL
      A0A0G2K9S4
      Conserved Domains (4) summary
      COG1196
      Location:11571439
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5022
      Location:71291
      COG5022; Myosin heavy chain [General function prediction only]
      cd15478
      Location:14761850
      Myo5a_CBD; Cargo binding domain of myosin 5a
      cd01380
      Location:83751
      MYSc_Myo5; class V myosin, motor domain
    4. XM_063264937.1XP_063121007.1  unconventional myosin-Va isoform X4

      UniProtKB/TrEMBL
      A0A0G2K9X3
    5. XM_063264938.1XP_063121008.1  unconventional myosin-Va isoform X5

      UniProtKB/TrEMBL
      A0A8I6A732
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