Cspg5 chondroitin sulfate proteoglycan 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cspg5provided by RGD
Official Full Name: chondroitin sulfate proteoglycan 5provided by RGD
Primary source: RGD:2431
See related: EnsemblRapid:ENSRNOG00000020833 AllianceGenome:RGD:2431
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ngc; Caleb
Summary: Involved in cytoskeleton organization; neurogenesis; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in Golgi apparatus and Golgi-associated vesicle membrane. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Orthologous to human CSPG5 (chondroitin sulfate proteoglycan 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 449.2) and Adrenal (RPKM 22.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (119098932..119113191)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (110220506..110234766)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (118333695..118348040)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
Title: Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex.
Rac1, Cdc42, and RhoG perform very specific and non-redundant functions at different levels of hierarchy in regulating dendritic tree complexity induced by CALEB/NGC
Title: Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity.
PI3K-Akt-mammalian target of rapamycin (mTOR) signaling pathway and PKC are important for CALEB/NGC-induced stimulation of dendritic branching. CALEB/NGC-induced spine morphogenesis is independent of PI3K but depends on PKC.
Title: The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity.
there is a glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C
Title: Glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C.
neuroglycan C is a novel component of midkine receptors involved in process elongation
Title: Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S2317 (e-PCR), detects polymorphism
- UniSTS:30258

AI604859 (e-PCR)
- UniSTS:164423

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell projection elongation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chondroitin sulfate proteoglycan 5

Names: acidic leucine-rich EGF-like domain-containing brain protein; neuroglycan C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019284.3 → NP_062157.2 chondroitin sulfate proteoglycan 5 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 2. This results in a shorter protein (isoform 1), compared to isoform 2.

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

F1M4R7

Related

ENSRNOP00000100671.1, ENSRNOT00000130232.1

Conserved Domains (2) summary

pfam06566
Location:34 → 281

Chon_Sulph_att; Chondroitin sulphate attachment domain

pfam06567
Location:452 → 543

Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain
NM_133652.2 → NP_598413.1 chondroitin sulfate proteoglycan 5 isoform 2 precursor

See identical proteins and their annotated locations for NP_598413.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longer isoform (2).

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q62831, Q9ERQ6

UniProtKB/TrEMBL

F1M4R7

Related

ENSRNOP00000028278.9, ENSRNOT00000028278.9

Conserved Domains (2) summary

pfam06566
Location:33 → 278

Chon_Sulph_att; Chondroitin sulphate attachment domain

pfam06567
Location:452 → 570

Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain