Lpcat1 lysophosphatidylcholine acyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lpcat1provided by RGD
Official Full Name: lysophosphatidylcholine acyltransferase 1provided by RGD
Primary source: RGD:1311599
See related: EnsemblRapid:ENSRNOG00000017930 AllianceGenome:RGD:1311599
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aytl2; RGD1311599
Summary: Enables 1-acylglycerol-3-phosphate O-acyltransferase activity and 1-acylglycerophosphocholine O-acyltransferase activity. Predicted to be involved in phosphatidylcholine acyl-chain remodeling and phospholipid biosynthetic process. Predicted to act upstream of or within several processes, including negative regulation of phosphatidylcholine biosynthetic process; positive regulation of protein catabolic process; and surfactant homeostasis. Predicted to be located in Golgi apparatus; lipid droplet; and membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human LPCAT1 (lysophosphatidylcholine acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 444.1), Spleen (RPKM 93.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (31594621..31644946, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (29766070..29816401, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (32379431..32429917, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data show the histological localization of PAF synthases and its receptor in the spinal cord following peripheral nerve injury.
Title: Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury.
Results suggest that lysophosphatidylcholine acyltransferase (LPCAT) plays a critical role in regulating surfactant phospholipid biosynthesis [LPCAT].
Title: Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells.
LPCAT1 transfers acetate from acetyl-CoA to lyso-PAF; its activity and expression are independent of inflammatory signals
Title: Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerophosphocholine O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-alkylglycerophosphocholine O-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-alkylglycerophosphocholine O-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-alkylglycerophosphocholine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables plasmalogen synthase activity	ISO Inferred from Sequence Orthology more info
enables plasmalogen synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within surfactant homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysophosphatidylcholine acyltransferase 1

Names: 1-acylglycerol-3-phosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; LPC acyltransferase 1; LPCAT-1; acetyl-CoA:lyso-PAF acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase; acyltransferase-like 2; lyso-PAF acetyltransferase; lysoPAFAT; lysoPC acyltransferase 1

NP_001094205.1

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

XP_038937140.1

EC 2.3.1.23

EC 2.3.1.25

EC 2.3.1.51

EC 2.3.1.67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100735.1 → NP_001094205.1 lysophosphatidylcholine acyltransferase 1

See identical proteins and their annotated locations for NP_001094205.1

Status: VALIDATED

Source sequence(s)

AB244983, AW533114, BF406111, CB718601, CK365681, CN544249, EB482109

UniProtKB/Swiss-Prot

Q1HAQ0

UniProtKB/TrEMBL

A0A8I6A2C9, A6JUX7

Related

ENSRNOP00000024111.6, ENSRNOT00000024111.7

Conserved Domains (3) summary

cd07991
Location:103 → 314

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

pfam13499
Location:421 → 480

EF-hand_7; EF-hand domain pair

cl08302
Location:384 → 446

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

31594621..31644946 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081212.2 → XP_038937140.1 lysophosphatidylcholine acyltransferase 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A2C9

Conserved Domains (3) summary

cd07991
Location:1 → 212

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

pfam13499
Location:319 → 378

EF-hand_7; EF-hand domain pair

cl08302
Location:282 → 344

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...