Serpine2 serpin family E member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpine2provided by RGD
Official Full Name: serpin family E member 2provided by RGD
Primary source: RGD:3748
See related: EnsemblRapid:ENSRNOG00000015461 AllianceGenome:RGD:3748
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CRG; PI-7; Pn-1; Spin4; Gdnpn1
Summary: Enables heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including dense core granule biogenesis; embryo implantation; and negative regulation of blood coagulation. Located in extracellular space and neuronal cell body. Biomarker of brain edema and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 252.1), Muscle (RPKM 172.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (88573138..88637252, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (81124746..81188866, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (85560852..85629410, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In cerebellum, thrombin can activate PAR-1 expression after ICH, and PN-1 appears quickly after Intracerebral hemorrhage in order to control the deleterious effect of thrombin.
Title: Expression of thrombin and its associated protein in cerebellum of human and rat after intracerebral hemorrhage.
data indicate that serpinE2 is up-regulated by oncogenic activation of Ras, BRAF and MEK1 and contributes to pro-neoplastic actions of ERK signaling in intestinal epithelial cells.
Title: The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis.
Expression of protease nexin-1 does not change significantly in the hippocampus following severe ischemic insult.
Title: Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors.
Up-regulation of PN-1 expression stabilizes and protects Dense-core secretory granule proteins against degradation.
Title: Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation.
Protease nexin-1 (PN-1) modulates the activity of endogenous and exogenous serine proteases in vascular smooth muscle; thrombin down-regulates PN-1 expression and thus may increase its own activity on cells.
Title: Protease nexin-1: a cellular serpin down-regulated by thrombin in rat aortic smooth muscle cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140749 (e-PCR)
- UniSTS:222815

AU047411 (e-PCR)
- UniSTS:110536

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glycosaminoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cerebellar granular layer morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebellar granular layer morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dense core granule biogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	IEP Inferred from Expression Pattern more info	PubMed
involved_in innervation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innervation	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in mating plug formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mating plug formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood coagulation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of plasminogen activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of plasminogen activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet aggregation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of timing of cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of timing of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
involved_in secretion by cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secretion by cell	ISO Inferred from Sequence Orthology more info
involved_in secretory granule organization	IDA Inferred from Direct Assay more info	PubMed
involved_in secretory granule organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secretory granule organization	ISO Inferred from Sequence Orthology more info
involved_in seminal vesicle epithelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within seminal vesicle epithelium development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in platelet alpha granule	IEA Inferred from Electronic Annotation more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glia-derived nexin

Names: Clozapine Regulated Gene; GDN; Glia-derived nexin/protease nexin I; glia-derived nexin / preotease nexin I; peptidase inhibitor 7; plasminogen activator inhibitor type 1; protease nexin 1; protease nexin I; protease nexin PN-1; serine (or cysteine) peptidase inhibitor, clade E, member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease inhibitor 4; serpin E2; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serpin peptidase inhibitor, clade E, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019197.1 → NP_062070.1 glia-derived nexin precursor

See identical proteins and their annotated locations for NP_062070.1

Status: VALIDATED

Source sequence(s)

BQ199747, CF110312, CK357674, DV726078, M17784

UniProtKB/Swiss-Prot

P07092

UniProtKB/TrEMBL

A0A0G2K2I7, A6JW83

Related

ENSRNOP00000072257.1, ENSRNOT00000077331.3

Conserved Domains (1) summary

cd19573
Location:21 → 395

serpinE2_GDN; serpin family E member 2, glia derived nexin (GDN)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

88573138..88637252 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245162.5 → XP_006245224.1 glia-derived nexin isoform X1

See identical proteins and their annotated locations for XP_006245224.1

UniProtKB/Swiss-Prot

P07092

UniProtKB/TrEMBL

A0A0G2K2I7, A6JW83

Conserved Domains (1) summary

cd19573
Location:21 → 395

serpinE2_GDN; serpin family E member 2, glia derived nexin (GDN)
XM_039083112.2 → XP_038939040.1 glia-derived nexin isoform X1

UniProtKB/Swiss-Prot

P07092

UniProtKB/TrEMBL

A0A0G2K2I7, A6JW83

Conserved Domains (1) summary

cd19573
Location:21 → 395

serpinE2_GDN; serpin family E member 2, glia derived nexin (GDN)
XM_063266812.1 → XP_063122882.1 glia-derived nexin isoform X1

UniProtKB/Swiss-Prot

P07092

UniProtKB/TrEMBL

A0A0G2K2I7, A6JW83