Ippk inositol-pentakisphosphate 2-kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ippkprovided by RGD
Official Full Name: inositol-pentakisphosphate 2-kinaseprovided by RGD
Primary source: RGD:1311271
See related: EnsemblRapid:ENSRNOG00000015631 AllianceGenome:RGD:1311271
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rIpk1; C9orf12; RGD1311271
Summary: Enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity. Predicted to be involved in inositol phosphate biosynthetic process and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be active in nucleus. Orthologous to human IPPK (inositol-pentakisphosphate 2-kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 51.8), Brain (RPKM 49.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (15396691..15441648, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (15190191..15235203, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (15604148..15643312, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inositol-pentakisphosphate 2-kinase

Names: 1,3,4,5,6-pentakisphosphate 2-kinase; inositol polyphosphate kinase 1; inositol-1,3,4,5,6-pentakisphosphate 2-kinase; ins(1,3,4,5,6)P5 2-kinase; insP5 2-kinase

NP_001008556.2

EC 2.7.1.158

XP_008769757.1

EC 2.7.1.158

XP_038951584.1

EC 2.7.1.158

XP_038951585.1

EC 2.7.1.158

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008556.2 → NP_001008556.2 inositol-pentakisphosphate 2-kinase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q5PXE9

UniProtKB/TrEMBL

A6J6W4

Related

ENSRNOP00000021022.3, ENSRNOT00000021022.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

15396691..15441648 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095656.2 → XP_038951584.1 inositol-pentakisphosphate 2-kinase isoform X2

UniProtKB/TrEMBL

G3V7Z5

Conserved Domains (1) summary

pfam06090
Location:13 → 389

Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
XM_008771535.4 → XP_008769757.1 inositol-pentakisphosphate 2-kinase isoform X1

See identical proteins and their annotated locations for XP_008769757.1

UniProtKB/Swiss-Prot

Q5PXE9

Conserved Domains (1) summary

pfam06090
Location:1 → 393

Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
XM_039095657.2 → XP_038951585.1 inositol-pentakisphosphate 2-kinase isoform X3

Conserved Domains (1) summary

pfam06090
Location:13 → 273

Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase