U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Med14 mediator complex subunit 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317343, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Med14provided by RGD
    Official Full Name
    mediator complex subunit 14provided by RGD
    Primary source
    RGD:1560170
    See related
    EnsemblRapid:ENSRNOG00000003792 AllianceGenome:RGD:1560170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560170
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and somatic stem cell population maintenance. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED14 (mediator complex subunit 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 137.9), Adrenal (RPKM 105.5) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Med14 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (12709406..12800642)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (10036749..10127910)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (10964035..11082403)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 133, member B like 1 Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene similar to human chromosome X open reading frame 38 Neighboring gene mitochondrial pyruvate carrier 1-like Neighboring gene ATPase H+ transporting accessory protein 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Novel glucocorticoid receptor coactivator effector mechanisms. Jenkins BD, et al. Trends Endocrinol Metab, 2001 Apr. PMID 11306337
    2. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. Wang Q, et al. J Biol Chem, 2002 Nov 8. PMID 12218053
    3. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Ito M, et al. Mol Cell, 1999 Mar. PMID 10198638
    4. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Ge K, et al. Nature, 2002 May 30. PMID 12037571
    5. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mediator of RNA polymerase II transcription subunit 14

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191727.2 → NP_001178656.1  mediator of RNA polymerase II transcription subunit 14

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D4A020
      Related
      ENSRNOP00000063505.1, ENSRNOT00000066480.4
      Conserved Domains (2) summary
      pfam03957
      Location:1052 → 1147
      Jun; Jun-like transcription factor
      pfam08638
      Location:57 → 244
      Med14; Mediator complex subunit MED14

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      12709406..12800642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099757.2 → XP_038955685.1  mediator of RNA polymerase II transcription subunit 14 isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q643
      Related
      ENSRNOP00000076132.2, ENSRNOT00000093181.3
      Conserved Domains (2) summary
      PHA03307
      Location:961 → 1160
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam08638
      Location:57 → 244
      Med14; Mediator complex subunit MED14
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous