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    Tfb2m transcription factor B2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289307, updated on 9-Dec-2024

    Summary

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    Symbol
    Tfb2mprovided by RGD
    Full Name
    transcription factor B2, mitochondrialprovided by RGD
    Primary source
    RGD:1307091
    See related
    EnsemblRapid:ENSRNOG00000002695 AllianceGenome:RGD:1307091
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mitochondrial transcription factor activity and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation and transcription initiation at mitochondrial promoter. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix. Orthologous to human TFB2M (transcription factor B2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 193.3), Muscle (RPKM 177.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tfb2m in Genome Data Viewer
    Location:
    13q26
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (93810859..93828678, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (91278889..91296709, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (97820493..97838275, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 3 Neighboring gene uncharacterized LOC108352579 Neighboring gene ribosomal protein L23,pseudogene 6 Neighboring gene uncharacterized LOC108352581 Neighboring gene consortin, connexin sorting protein Neighboring gene saccharopine dehydrogenase (putative)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription. Watanabe A, et al. Cardiovasc Res, 2011 Apr 1. PMID 21113058
    2. Structural Basis of Mitochondrial Transcription Initiation. Hillen HS, et al. Cell, 2017 Nov 16. PMID 29149603, Free PMC Article
    3. Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro. Litonin D, et al. J Biol Chem, 2010 Jun 11. PMID 20410300, Free PMC Article
    4. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Falkenberg M, et al. Nat Genet, 2002 Jul. PMID 12068295
    5. The layered structure of human mitochondrial DNA nucleoids. Bogenhagen DF, et al. J Biol Chem, 2008 Feb 8. PMID 18063578

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription in cardiac myocytes.
      Title: Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitochondrial transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitochondrial transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitochondrial transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at mitochondrial promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at mitochondrial promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at mitochondrial promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dimethyladenosine transferase 2, mitochondrial
    Names
    S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
    dimethyladenosine transferase 2, mitochondrial-like
    mitochondrial 12S rRNA dimethylase 2
    mitochondrial transcription factor B2
    mtTFB2
    NP_001008294.1
    XP_008768039.1
    XP_038946480.1
    XP_038946481.1
    XP_063128234.1
    XP_063128235.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008293.1 → NP_001008294.1  dimethyladenosine transferase 2, mitochondrial

      See identical proteins and their annotated locations for NP_001008294.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085870
      UniProtKB/Swiss-Prot
      Q5U2T7
      UniProtKB/TrEMBL
      A6JGF4
      Related
      ENSRNOP00000003618.3, ENSRNOT00000003618.5
      Conserved Domains (1) summary
      cl17173
      Location:82 → 378
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      93810859..93828678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090552.2 → XP_038946480.1  dimethyladenosine transferase 2, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:84 → 270
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_008769817.4 → XP_008768039.1  dimethyladenosine transferase 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZY51
      Related
      ENSRNOP00000084899.1, ENSRNOT00000086734.3
      Conserved Domains (1) summary
      cl17173
      Location:84 → 266
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_063272164.1 → XP_063128234.1  dimethyladenosine transferase 2, mitochondrial isoform X2

    4. XM_039090553.2 → XP_038946481.1  dimethyladenosine transferase 2, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:84 → 266
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_063272165.1 → XP_063128235.1  dimethyladenosine transferase 2, mitochondrial isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2T7.1 GenPept UniProtKB/Swiss-Prot:Q5U2T7

    Gene LinkOut

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