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    Cebpa CCAAT/enhancer binding protein alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24252, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cebpaprovided by RGD
    Official Full Name
    CCAAT/enhancer binding protein alphaprovided by RGD
    Primary source
    RGD:2326
    See related
    EnsemblRapid:ENSRNOG00000010918 AllianceGenome:RGD:2326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DBPCEP
    Summary
    This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Aug 2014]
    Orthologs
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    Genomic context

    See Cebpa in Genome Data Viewer
    Location:
    1q21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (96896584..96899256)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (87759631..87762303)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91363492..91366164)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene CCAAT/enhancer binding protein gamma Neighboring gene uncharacterized LOC102555648 Neighboring gene uncharacterized LOC102555707 Neighboring gene uncharacterized LOC102555770

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 33
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding PubMed 
    enables DNA-binding transcription factor binding  
    enables HMG box domain binding PubMed 
    enables RNA polymerase I transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase I transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables STAT family protein binding  
    enables chromatin DNA binding  
    enables chromatin binding  
    enables histone deacetylase binding PubMed 
    enables identical protein binding  
    enables kinase binding  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein heterodimerization activity PubMed 
    enables protein homodimerization activity PubMed 
    enables protein homodimerization activity PubMed 
    enables protein-containing complex binding PubMed 
    contributes_to sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables transcription cis-regulatory region binding  
    Items 1 - 25 of 33
    Items 1 - 25 of 76
    Process Evidence Code Pubs
    involved_in DNA-templated transcription  
    acts_upstream_of_or_within Notch signaling pathway  
    involved_in acute-phase response PubMed 
    involved_in animal organ regeneration PubMed 
    acts_upstream_of_or_within brown fat cell differentiation  
    involved_in cell differentiation PubMed 
    acts_upstream_of cell population proliferation  
    acts_upstream_of_or_within cellular response to lithium ion  
    acts_upstream_of_or_within cellular response to organic cyclic compound  
    acts_upstream_of_or_within cellular response to tumor necrosis factor  
    involved_in cellular response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within cholesterol metabolic process  
    acts_upstream_of_or_within embryonic placenta development  
    involved_in energy homeostasis  
    acts_upstream_of_or_within epithelial cell maturation  
    involved_in fat cell differentiation PubMed 
    acts_upstream_of_or_within fat cell differentiation  
    involved_in fat cell differentiation  
    involved_in fat cell differentiation  
    involved_in glucose homeostasis  
    involved_in glucose homeostasis  
    involved_in granulocyte differentiation  
    involved_in granulocyte differentiation  
    acts_upstream_of hematopoietic stem cell proliferation  
    acts_upstream_of_or_within inner ear development  
    involved_in interleukin-6-mediated signaling pathway  
    involved_in lipid homeostasis  
    involved_in lipid homeostasis  
    involved_in liver development PubMed 
    acts_upstream_of_or_within liver development  
    involved_in liver development  
    involved_in liver development  
    acts_upstream_of_or_within lung development  
    involved_in lung development  
    involved_in lung development  
    acts_upstream_of_or_within macrophage differentiation  
    involved_in memory PubMed 
    acts_upstream_of_or_within mitochondrion organization  
    involved_in myeloid cell differentiation  
    involved_in myeloid cell differentiation  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of cell cycle  
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of hematopoietic stem cell proliferation  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in osteoblast development PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription initiation  
    involved_in positive regulation of fat cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of fat cell differentiation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of macrophage activation  
    acts_upstream_of_or_within positive regulation of osteoblast differentiation  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to dexamethasone PubMed 
    involved_in response to nutrient PubMed 
    involved_in response to phenylpropanoid PubMed 
    involved_in response to vitamin B2 PubMed 
    involved_in transcription by RNA polymerase I  
    involved_in transcription by RNA polymerase I  
    acts_upstream_of_or_within urea cycle  
    acts_upstream_of_or_within white fat cell differentiation  
    Items 1 - 25 of 76
    Component Evidence Code Pubs
    part_of C/EBP complex  
    part_of CHOP-C/EBP complex PubMed 
    part_of CHOP-C/EBP complex  
    part_of RNA polymerase II transcription regulator complex  
    part_of Rb-E2F complex PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in nuclear matrix PubMed 
    located_in nucleolus PubMed 
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus PubMed 
    part_of protein-containing complex PubMed 
    part_of transcription regulator complex PubMed 
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    CCAAT/enhancer-binding protein alpha
    Names
    C/EBP alpha
    CAAT/enhancer-binding protein, DNA-binding protein
    CCAAT/enhancer binding protein (C/EBP), alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287577.1NP_001274506.1  CCAAT/enhancer-binding protein alpha isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (CUG) site, and also from three conserved downstream, in-frame AUG sites. The isoform (c, also known as extended) represented in this RefSeq results from translation initiation at the upstream CUG start codon. Isoform c is the longest isoform.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P05554
      Conserved Domains (1) summary
      cd14711
      Location:317377
      bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain
    2. NM_001287578.1NP_001274507.1  CCAAT/enhancer-binding protein alpha isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (CUG) site, and also from three conserved downstream, in-frame AUG sites. The isoform (d) represented in this RefSeq results from translation initiation at the second AUG start codon. Isoform d has a shorter N-terminus, compared to isoform c.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P05554
      Conserved Domains (1) summary
      cd14711
      Location:266326
      bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain
    3. NM_001287579.1NP_001274508.1  CCAAT/enhancer-binding protein alpha isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (CUG) site, and also from three conserved downstream, in-frame AUG sites. The isoform (b) represented in this RefSeq results from translation initiation at the third AUG start codon. Isoform b has a shorter N-terminus, compared to isoform c.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P05554
      Conserved Domains (1) summary
      cd14711
      Location:163223
      bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain
    4. NM_012524.3NP_036656.1  CCAAT/enhancer-binding protein alpha isoform a

      See identical proteins and their annotated locations for NP_036656.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (CUG) site, and also from three conserved downstream, in-frame AUG sites. The isoform (a) represented in this RefSeq results from translation initiation at the first AUG start codon. Isoform a has a shorter N-terminus, compared to isoform c.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P05554
      UniProtKB/TrEMBL
      A6JAA1
      Related
      ENSRNOP00000104202.1, ENSRNOT00000014517.7
      Conserved Domains (1) summary
      cd14711
      Location:280340
      bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      96896584..96899256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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