Amer2 APC membrane recruitment protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Amer2provided by RGD
Official Full Name: APC membrane recruitment protein 2provided by RGD
Primary source: RGD:1559605
See related: AllianceGenome:RGD:1559605
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam123a; RGD1559605
Summary: Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in plasma membrane. Orthologous to human AMER2 (APC membrane recruitment protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 52.6), Testes (RPKM 35.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (38701509..38711817)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (34525352..34535660)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (40663183..40667705)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability.
Title: Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.

Submit: New GeneRIF Correction

General gene information

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Markers

BF400972 (e-PCR)
- UniSTS:245054

RH135443 (e-PCR)
- UniSTS:218720

Fam123a (e-PCR), detects polymorphism
- UniSTS:531047

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: APC membrane recruitment protein 2

Names: family with sequence similarity 123A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399520.1 → NP_001386449.1 APC membrane recruitment protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A0G2JWK6

Conserved Domains (1) summary

pfam09422
Location:93 → 588

WTX; WTX protein