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    Gipr gastric inhibitory polypeptide receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25024, updated on 4-Jan-2025

    Summary

    Official Symbol
    Giprprovided by RGD
    Official Full Name
    gastric inhibitory polypeptide receptorprovided by RGD
    Primary source
    RGD:2689
    See related
    EnsemblRapid:ENSRNOG00000015860 AllianceGenome:RGD:2689
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gippr; RATGIPPR
    Summary
    Enables gastric inhibitory peptide receptor activity and peptide hormone binding activity. Involved in several processes, including desensitization of G protein-coupled receptor signaling pathway; gastric inhibitory peptide signaling pathway; and positive regulation of insulin secretion. Predicted to be active in plasma membrane. Used to study type 2 diabetes mellitus. Biomarker of hyperglycemia. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; and obesity. Orthologous to human GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 16.0), Thymus (RPKM 6.2) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Gipr in Genome Data Viewer
    Location:
    1q21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87932316..87956084, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78804287..78814462, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80063047..80073223, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glutaminyl-peptide cyclotransferase-like Neighboring gene small nuclear ribonucleoprotein D2 polypeptide Neighboring gene EMAP like 2 Neighboring gene microRNA 330 Neighboring gene G protein-coupled receptor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity  
    enables gastric inhibitory peptide receptor activity  
    enables gastric inhibitory peptide receptor activity PubMed 
    enables gastric inhibitory peptide receptor activity  
    enables gastric inhibitory peptide receptor activity  
    enables glucagon family peptide binding  
    enables peptide hormone binding  
    enables peptide hormone binding PubMed 
    enables peptide hormone binding  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway  
    involved_in cell surface receptor signaling pathway  
    involved_in desensitization of G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within endocrine pancreas development  
    involved_in gastric inhibitory peptide signaling pathway  
    involved_in gastric inhibitory peptide signaling pathway PubMed 
    involved_in gastric inhibitory peptide signaling pathway  
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in positive regulation of insulin secretion PubMed 
    involved_in positive regulation of insulin secretion  
    involved_in response to axon injury PubMed 
    involved_in response to calcium ion PubMed 
    involved_in response to fatty acid PubMed 
    involved_in response to glucose PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    gastric inhibitory polypeptide receptor
    Names
    GIP-R
    gastric inhibitory peptide receptor
    glucose-dependent insulinotropic polypeptide receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012714.2NP_036846.1  gastric inhibitory polypeptide receptor precursor

      See identical proteins and their annotated locations for NP_036846.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P43219
      UniProtKB/TrEMBL
      A0A8I5ZT57, A6J8K3
      Related
      ENSRNOP00000021456.1, ENSRNOT00000021456.4
      Conserved Domains (2) summary
      pfam00002
      Location:131385
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:55118
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      87932316..87956084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281146.1XP_063137216.1  gastric inhibitory polypeptide receptor isoform X1

      UniProtKB/Swiss-Prot
      P43219
      UniProtKB/TrEMBL
      A0A8I5ZT57, A6J8K3
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