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    Ldhc lactate dehydrogenase C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29634, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ldhcprovided by RGD
    Official Full Name
    lactate dehydrogenase Cprovided by RGD
    Primary source
    RGD:69366
    See related
    EnsemblRapid:ENSRNOG00000013103 AllianceGenome:RGD:69366
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ldh3
    Summary
    Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process and pyruvate catabolic process. Predicted to act upstream of or within ATP biosynthetic process; flagellated sperm motility; and lactate biosynthetic process from pyruvate. Predicted to be located in cytoplasm and motile cilium. Predicted to be active in cytosol and mitochondrion. Orthologous to human LDHC (lactate dehydrogenase C). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 1668.1) See more
    Orthologs
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    Genomic context

    See Ldhc in Genome Data Viewer
    Location:
    1q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (106522140..106539649)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (97385984..97403382)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102914875..102931843)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene general transcription factor IIH subunit 1 Neighboring gene uncharacterized LOC102552634 Neighboring gene uncharacterized LOC120099812 Neighboring gene lactate dehydrogenase A Neighboring gene tumor susceptibility 101 Neighboring gene UEV and lactate/malate dehydrogenase domains

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cilium  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    is_active_in cytosol  
    is_active_in mitochondrion  
    located_in motile cilium  
    located_in motile cilium  

    General protein information

    Preferred Names
    L-lactate dehydrogenase C chain
    Names
    LDH testis subunit
    LDH-C
    LDH-X
    lactate dehydrogenase 3, C chain, sperm specific
    NP_058962.2
    XP_006229295.1
    XP_008757566.1
    XP_017444552.1
    XP_038965574.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017266.2NP_058962.2  L-lactate dehydrogenase C chain

      See identical proteins and their annotated locations for NP_058962.2

      Status: PROVISIONAL

      Source sequence(s)
      BC078862
      UniProtKB/Swiss-Prot
      P19629
      UniProtKB/TrEMBL
      A6JBD6, F7FDE8, Q6AYX2
      Related
      ENSRNOP00000017851.3, ENSRNOT00000017851.8
      Conserved Domains (1) summary
      cd05293
      Location:18329
      LDH_1; A subgroup of L-lactate dehydrogenases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      106522140..106539649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109646.2XP_038965574.2  L-lactate dehydrogenase C chain isoform X1

      UniProtKB/Swiss-Prot
      P19629
    2. XM_008759344.4XP_008757566.1  L-lactate dehydrogenase C chain isoform X2

      UniProtKB/Swiss-Prot
      P19629
      Conserved Domains (2) summary
      cd05293
      Location:22333
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:29329
      L-LDH-NAD; L-lactate dehydrogenase
    3. XM_006229233.5XP_006229295.1  L-lactate dehydrogenase C chain isoform X3

      See identical proteins and their annotated locations for XP_006229295.1

      UniProtKB/Swiss-Prot
      P19629
      UniProtKB/TrEMBL
      A6JBD6, F7FDE8, Q6AYX2
      Related
      ENSRNOP00000071562.3, ENSRNOT00000082718.3
      Conserved Domains (1) summary
      cd05293
      Location:18329
      LDH_1; A subgroup of L-lactate dehydrogenases
    4. XM_017589063.3XP_017444552.1  L-lactate dehydrogenase C chain isoform X4

      UniProtKB/Swiss-Prot
      P19629
      Related
      ENSRNOP00000075021.2, ENSRNOT00000090520.3
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