Pttg1 PTTG1 regulator of sister chromatid separation, securin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pttg1provided by RGD
Official Full Name: PTTG1 regulator of sister chromatid separation, securinprovided by RGD
Primary source: RGD:68359
See related: EnsemblRapid:ENSRNOG00000003802 AllianceGenome:RGD:68359
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pttg
Summary: Enables heat shock protein binding activity and ribosome binding activity. Involved in negative regulation of cell population proliferation and regulation of cell growth. Predicted to be located in cytosol. Predicted to be active in axoneme and nucleus. Orthologous to several human genes including PTTG1 (PTTG1 regulator of sister chromatid separation, securin) and PTTG3P (pituitary tumor-transforming 3, pseudogene). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Testes (RPKM 100.1), Spleen (RPKM 85.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (28394940..28406410, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (27893466..27904965, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (29014332..29026088, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTTG1 promotes CD34[+]CD45[+] cells to repair the pulmonary vascular barrier via activating the VEGF-bFGF/PI3K/AKT/eNOS signaling pathway in rats with phosgene-induced acute lung injury.
Title: PTTG1 promotes CD34(+)CD45(+) cells to repair the pulmonary vascular barrier via activating the VEGF-bFGF/PI3K/AKT/eNOS signaling pathway in rats with phosgene-induced acute lung injury.
The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.
Title: The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.
EAP1 (Pttg1) gene may be involved in the neuroendocrine control of female puberty in correlation with the kisspeptin signaling.
Title: Expression of EAP1 and CUX1 in the hypothalamus of female rats and relationship with KISS1 and GnRH.
Altered Cx43 expression modulates Pituitary tumor transforming gene expression, which correlates with prolactinoma development.
Title: Effects of silencing connexin43 on expression of pituitary tumor-transforming gene in prolactinomas.
pttg1 could predict inter-individual susceptibility to D-galactosamine induced hepatotoxicity
Title: Expression levels of pituitary tumor transforming 1 and glutathione-S-transferase theta 3 are associated with the individual susceptibility to D-galactosamine-induced hepatotoxicity.
calcium sensing receptor stimulates the synthesis of PTTG mRNA in a nonmetastasizing model for humoral hypercalcemia of malignancy and, in the process, might induce angiogenesis via VEGF.
Title: Calcium-sensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Wox45 (e-PCR)
- UniSTS:239259

RH133996 (e-PCR)
- UniSTS:217278

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in homologous chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homologous chromosome segregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axoneme	ISO Inferred from Sequence Orthology more info
is_active_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: securin

Names: Pituitary tumor transforming; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022391.3 → NP_071786.1 securin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P97613

UniProtKB/TrEMBL

A6HDM7, B0BMT1

Conserved Domains (1) summary

pfam04856
Location:1 → 188

Securin; Securin sister-chromatid separation inhibitor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

28394940..28406410 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086789.2 → XP_038942717.1 securin isoform X2

UniProtKB/TrEMBL

A0A8I6A1P6, A6HDM7

Related

ENSRNOP00000086678.1, ENSRNOT00000093944.2

Conserved Domains (1) summary

pfam04856
Location:1 → 173

Securin; Securin sister-chromatid separation inhibitor
XM_063269814.1 → XP_063125884.1 securin isoform X2

UniProtKB/TrEMBL

A0A8I6A1P6, A6HDM7
XM_063269813.1 → XP_063125883.1 securin isoform X1

UniProtKB/Swiss-Prot

P97613

UniProtKB/TrEMBL

A6HDM7, B0BMT1
XM_006246142.3 → XP_006246204.1 securin isoform X1

UniProtKB/Swiss-Prot

P97613

UniProtKB/TrEMBL

A6HDM7, B0BMT1

Conserved Domains (1) summary

pfam04856
Location:1 → 188

Securin; Securin sister-chromatid separation inhibitor
XM_006246143.5 → XP_006246205.1 securin isoform X1

UniProtKB/Swiss-Prot

P97613

UniProtKB/TrEMBL

A6HDM7, B0BMT1

Conserved Domains (1) summary

pfam04856
Location:1 → 188

Securin; Securin sister-chromatid separation inhibitor
XM_006246144.3 → XP_006246206.1 securin isoform X1

UniProtKB/Swiss-Prot

P97613

UniProtKB/TrEMBL

A6HDM7, B0BMT1

Related

ENSRNOP00000005070.2, ENSRNOT00000005070.7

Conserved Domains (1) summary

pfam04856
Location:1 → 188

Securin; Securin sister-chromatid separation inhibitor
XM_063269812.1 → XP_063125882.1 securin isoform X1

UniProtKB/Swiss-Prot

P97613

UniProtKB/TrEMBL

A6HDM7, B0BMT1