Grpel1 GrpE-like 1, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grpel1provided by RGD
Official Full Name: GrpE-like 1, mitochondrialprovided by RGD
Primary source: RGD:70947
See related: EnsemblRapid:ENSRNOG00000006593 AllianceGenome:RGD:70947
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GrpE1; GrpE#1
Summary: Enables ATPase activator activity; ATPase binding activity; and identical protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrial matrix and nucleoplasm. Predicted to be part of PAM complex, Tim23 associated import motor. Biomarker of middle cerebral artery infarction. Orthologous to human GRPEL1 (GrpE like 1, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 726.8), Liver (RPKM 629.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (78517049..78522868, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (74292023..74298243, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (79458951..79464782, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

reverse transcription-polymerase chain reaction and in situ hybridization analyses showed significant induction of GrpE mRNA in the ischemic cortex
Title: Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PAM complex, Tim23 associated import motor	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: grpE protein homolog 1, mitochondrial

Names: mt-GrpE#1; stress-inducible chaperone mt-GrpE#1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024487.4 → NP_077813.1 grpE protein homolog 1, mitochondrial precursor

See identical proteins and their annotated locations for NP_077813.1

Status: PROVISIONAL

Source sequence(s)

U62940

UniProtKB/Swiss-Prot

P97576, Q4QRA3

UniProtKB/TrEMBL

A0A8I6AMG9, A6IJY3

Conserved Domains (1) summary

cd00446
Location:72 → 213

GrpE; nucleotide exchange factor GrpE