Exosc10 exosome component 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Exosc10provided by RGD
Official Full Name: exosome component 10provided by RGD
Primary source: RGD:1593248
See related: EnsemblRapid:ENSRNOG00000010719 AllianceGenome:RGD:1593248
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PM/Scl100
Summary: Predicted to enable 3'-5'-RNA exonuclease activity; single-stranded RNA binding activity; and telomerase RNA binding activity. Predicted to be involved in several processes, including RNA 3'-end processing; RNA catabolic process; and negative regulation of telomere maintenance via telomerase. Predicted to act upstream of or within positive regulation of mRNA cis splicing, via spliceosome. Predicted to be located in cytosol; euchromatin; and nucleoplasm. Predicted to be part of nuclear exosome (RNase complex) and small-subunit processome. Predicted to be active in nucleolus. Orthologous to human EXOSC10 (exosome component 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 176.3), Heart (RPKM 166.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (164278414..164302067)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (158995313..159018940)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (165374964..165398195)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5'-RNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CUT catabolic process	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in RNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in RNA processing	ISO Inferred from Sequence Orthology more info
involved_in TRAMP-dependent tRNA surveillance pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in histone mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in histone mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in maturation of 5.8S rRNA	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in nuclear mRNA surveillance	ISO Inferred from Sequence Orthology more info
involved_in nuclear polyadenylation-dependent CUT catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent antisense transcript catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent rRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent rRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear polyadenylation-dependent snRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent snoRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in poly(A)-dependent snoRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of mRNA cis splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of telomerase RNA localization to Cajal body	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
part_of exosome (RNase complex)	ISO Inferred from Sequence Orthology more info
part_of nuclear exosome (RNase complex)	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear exosome (RNase complex)	IEA Inferred from Electronic Annotation more info
part_of nuclear exosome (RNase complex)	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: exosome complex component 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399229.1 → NP_001386158.1 exosome complex component 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

D4A1X2

UniProtKB/TrEMBL

A0A8I6AGF9, A6IU72

Related

ENSRNOP00000014629.3, ENSRNOT00000014629.7

Conserved Domains (3) summary

cd06147
Location:284 → 474

Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins

smart00341
Location:503 → 583

HRDC; Helicase and RNase D C-terminal

pfam08066
Location:47 → 133

PMC2NT; PMC2NT (NUC016) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

164278414..164302067

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111357.2 → XP_038967285.1 exosome complex component 10 isoform X1

Conserved Domains (3) summary

cd06147
Location:284 → 474

Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins

smart00341
Location:503 → 583

HRDC; Helicase and RNase D C-terminal

pfam08066
Location:47 → 133

PMC2NT; PMC2NT (NUC016) domain
XM_063287834.1 → XP_063143904.1 exosome complex component 10 isoform X2