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    Cks2 CDC28 protein kinase regulatory subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498709, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cks2provided by RGD
    Official Full Name
    CDC28 protein kinase regulatory subunit 2provided by RGD
    Primary source
    RGD:1562047
    See related
    EnsemblRapid:ENSRNOG00000079240 AllianceGenome:RGD:1562047
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562047
    Summary
    Predicted to enable several functions, including cyclin-dependent protein serine/threonine kinase activator activity; histone binding activity; and ubiquitin binding activity. Predicted to be involved in regulation of mitotic cell cycle. Predicted to act upstream of or within several processes, including fibroblast proliferation; mitotic cell cycle phase transition; and regulation of transcription by RNA polymerase II. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Orthologous to human CKS2 (CDC28 protein kinase regulatory subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 261.6), Testes (RPKM 194.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cks2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (13722360..13727519, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (13570611..13575770, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (13587664..13593423, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene semaphorin 4D Neighboring gene uncharacterized LOC134482683 Neighboring gene SECIS binding protein 2 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene SHC adaptor protein 3 Neighboring gene sphingosine-1-phosphate receptor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    General protein information

    Preferred Names
    cyclin-dependent kinases regulatory subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126083.1NP_001119555.1  cyclin-dependent kinases regulatory subunit 2

      See identical proteins and their annotated locations for NP_001119555.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162005
      UniProtKB/TrEMBL
      B1WC51
      Related
      ENSRNOP00000108083.1, ENSRNOT00000165195.1
      Conserved Domains (1) summary
      pfam01111
      Location:873
      CKS; Cyclin-dependent kinase regulatory subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      13722360..13727519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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