Sash1 SAM and SH3 domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sash1provided by RGD
Official Full Name: SAM and SH3 domain containing 1provided by RGD
Primary source: RGD:1566017
See related: EnsemblRapid:ENSRNOG00000013160 AllianceGenome:RGD:1566017
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566017
Summary: Predicted to enable G-protein alpha-subunit binding activity; mitogen-activated protein kinase kinase kinase binding activity; and molecular adaptor activity. Predicted to be involved in positive regulation of non-canonical NF-kappaB signal transduction and regulation of epithelial cell migration. Predicted to act upstream of or within several processes, including positive regulation of angiogenesis; positive regulation of signal transduction; and regulation of protein modification process. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human SASH1 (SAM and SH3 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 165.4), Kidney (RPKM 153.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p13

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (4940207..5238777, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (3119915..3418536, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (2782905..2950749, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of SASH1, an astrocyte differentiation-related gene, contributes to functional recovery in spinal cord injury.
Title: Depletion of SASH1, an astrocyte differentiation-related gene, contributes to functional recovery in spinal cord injury.
Astrocyte-derived exosomes express HMGB1, though expression is higher in C6 glioma. Extracellular HMGB1 decreases SASH1 expression, exosomal HMGB1 enhances it. Exosomal and extracellular HMGB1 have opposing effects on SASH1 gene regulation.
Title: Exosomal and extracellular HMGB1 have opposite effects on SASH1 expression in rat astrocytes and glioma C6 cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein autoubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SAM and SH3 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427579.1 → NP_001414508.1 SAM and SH3 domain-containing protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6G377, A0A8I6GLI1

Related

ENSRNOP00000076776.2, ENSRNOT00000095438.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

4940207..5238777 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101481.2 → XP_038957409.1 SAM and SH3 domain-containing protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I6G377

Conserved Domains (5) summary

cd09492
Location:1278 → 1347

SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2

cd09559
Location:748 → 812

SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1

cd11967
Location:671 → 727

SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1

PHA03247
Location:936 → 1163

PHA03247; large tegument protein UL36; Provisional

pfam12485
Location:517 → 669

SLY; Lymphocyte signaling adaptor protein
XM_039101480.2 → XP_038957408.1 SAM and SH3 domain-containing protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6A020

Conserved Domains (5) summary

cd09492
Location:1281 → 1350

SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2

cd09559
Location:751 → 815

SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1

cd11967
Location:674 → 730

SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1

PHA03247
Location:939 → 1166

PHA03247; large tegument protein UL36; Provisional

pfam12485
Location:520 → 672

SLY; Lymphocyte signaling adaptor protein
XM_039101479.2 → XP_038957407.1 SAM and SH3 domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6G377

Related

ENSRNOP00000096222.2, ENSRNOT00000112617.2

Conserved Domains (5) summary

cd09492
Location:1323 → 1392

SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2

cd09559
Location:793 → 857

SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1

cd11967
Location:716 → 772

SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1

PHA03247
Location:981 → 1208

PHA03247; large tegument protein UL36; Provisional

pfam12485
Location:562 → 714

SLY; Lymphocyte signaling adaptor protein
XM_039101484.2 → XP_038957412.1 SAM and SH3 domain-containing protein 1 isoform X5

UniProtKB/TrEMBL

F1LU97

Conserved Domains (5) summary

cd09492
Location:1087 → 1156

SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2

cd09559
Location:557 → 621

SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1

cd11967
Location:480 → 536

SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1

PHA03247
Location:745 → 972

PHA03247; large tegument protein UL36; Provisional

pfam12485
Location:326 → 478

SLY; Lymphocyte signaling adaptor protein
XM_039101486.2 → XP_038957414.1 SAM and SH3 domain-containing protein 1 isoform X7

UniProtKB/TrEMBL

A0A8I5Y723, F1LU97

Conserved Domains (5) summary

cd09492
Location:925 → 994

SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2

cd09559
Location:395 → 459

SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1

cd11967
Location:318 → 374

SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1

PHA03247
Location:583 → 810

PHA03247; large tegument protein UL36; Provisional

pfam12485
Location:162 → 316

SLY; Lymphocyte signaling adaptor protein
XM_039101483.2 → XP_038957411.1 SAM and SH3 domain-containing protein 1 isoform X4

UniProtKB/TrEMBL

F1LU97

Conserved Domains (5) summary

cd09492
Location:1099 → 1168

SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2

cd09559
Location:569 → 633

SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1

cd11967
Location:492 → 548

SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1

PHA03247
Location:757 → 984

PHA03247; large tegument protein UL36; Provisional

pfam12485
Location:338 → 490

SLY; Lymphocyte signaling adaptor protein
XM_039101485.2 → XP_038957413.1 SAM and SH3 domain-containing protein 1 isoform X6

UniProtKB/TrEMBL

F1LU97

Conserved Domains (5) summary

cd09492
Location:1046 → 1115

SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2

cd09559
Location:516 → 580

SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1

cd11967
Location:439 → 495

SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1

PHA03247
Location:704 → 931

PHA03247; large tegument protein UL36; Provisional

pfam12485
Location:285 → 437

SLY; Lymphocyte signaling adaptor protein