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    Fam171a1 family with sequence similarity 171, member A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680259, updated on 9-Dec-2024

    Summary

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    Symbol
    Fam171a1provided by RGD
    Full Name
    family with sequence similarity 171, member A1provided by RGD
    Primary source
    RGD:1594172
    See related
    EnsemblRapid:ENSRNOG00000016534 AllianceGenome:RGD:1594172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of cell shape and stress fiber assembly. Predicted to be located in plasma membrane. Orthologous to human FAM171A1 (family with sequence similarity 171 member A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 17297.1), Thymus (RPKM 17232.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam171a1 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (79933742..80057495, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (75024582..75148348, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (79030150..79149480, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene ribonuclease P/MRP subunit p38 Neighboring gene N-myristoyltransferase 2 Neighboring gene uncharacterized LOC134482749 Neighboring gene uncharacterized LOC134482750 Neighboring gene integrin subunit alpha 8 Neighboring gene uncharacterized LOC120097958 Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape and Invasive Growth. Rasila T, et al. Am J Pathol, 2019 Jan. PMID 30312582
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM171A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432313.1 → NP_001419242.1  protein FAM171A1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6AEW7, D4A7Y4

    2. NM_001432314.1 → NP_001419243.1  protein FAM171A1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6JM27

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      79933742..80057495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096412.1 → XP_038952340.1  protein FAM171A1 isoform X3

      UniProtKB/TrEMBL
      A6JM27
      Conserved Domains (1) summary
      pfam10577
      Location:1 → 766
      UPF0560; Uncharacterized protein family UPF0560

    2. XM_039096410.1 → XP_038952338.1  protein FAM171A1 isoform X1

      UniProtKB/TrEMBL
      D4A7Y4
      Related
      ENSRNOP00000111460.1, ENSRNOT00000158378.1
      Conserved Domains (1) summary
      pfam10577
      Location:52 → 909
      UPF0560; Uncharacterized protein family UPF0560

    3. XM_039096411.1 → XP_038952339.1  protein FAM171A1 isoform X2

      Related
      ENSRNOP00000091660.1, ENSRNOT00000106690.2
      Conserved Domains (1) summary
      pfam10577
      Location:34 → 891
      UPF0560; Uncharacterized protein family UPF0560

    4. XM_039096413.2 → XP_038952341.1  protein FAM171A1 isoform X3

      Conserved Domains (1) summary
      pfam10577
      Location:1 → 766
      UPF0560; Uncharacterized protein family UPF0560
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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