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    Socs6 suppressor of cytokine signaling 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307200, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Socs6provided by RGD
    Official Full Name
    suppressor of cytokine signaling 6provided by RGD
    Primary source
    RGD:1304632
    See related
    EnsemblRapid:ENSRNOG00000038212 AllianceGenome:RGD:1304632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling adaptor activity. Predicted to be involved in intracellular signal transduction; negative regulation of signal transduction; and protein ubiquitination. Predicted to act upstream of or within negative regulation of T cell activation; proteasomal protein catabolic process; and regulation of growth. Predicted to be located in immunological synapse. Orthologous to human SOCS6 (suppressor of cytokine signaling 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 164.4), Muscle (RPKM 128.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Socs6 in Genome Data Viewer
    Location:
    18q13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (84386587..84413927, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (82111866..82139193, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (85962729..85981125, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694260 Neighboring gene uncharacterized LOC102546314 Neighboring gene replication protein A1, pseudogene 1 Neighboring gene ATP synthase peripheral stalk-membrane subunit b, pseudogene 2 Neighboring gene chimerin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BC-Box Motif in SOCS6 Induces Differentiation of Epidermal Stem Cells into GABAnergic Neurons. Yoshizumi T, et al. Int J Mol Sci, 2020 Jul 13. PMID 32668737, Free PMC Article
    2. Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition. Gupta S, et al. PLoS One, 2011. PMID 22125600, Free PMC Article
    3. miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6. Zhang W, et al. Oxid Med Cell Longev, 2020. PMID 32587662, Free PMC Article
    4. SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation. Choi YB, et al. J Biol Chem, 2010 Mar 5. PMID 20007709, Free PMC Article
    5. Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance. Mooney RA, et al. J Biol Chem, 2001 Jul 13. PMID 11342531

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BC-Box Motif in SOCS6 Induces Differentiation of Epidermal Stem Cells into GABAnergic Neurons.
      Title: BC-Box Motif in SOCS6 Induces Differentiation of Epidermal Stem Cells into GABAnergic Neurons.
    2. miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6.
      Title: miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6.
    3. Findings define a molecular mechanism for Jak2/Stat5 mediated Suppressor of cytokine signalling-6 (SOCS6) signalling.
      Title: Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    NOT acts_upstream_of_or_within intracellular glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of cytokine signaling 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271149.3 → NP_001258078.1  suppressor of cytokine signaling 6

      See identical proteins and their annotated locations for NP_001258078.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      D3ZS84
      Conserved Domains (2) summary
      cd10387
      Location:385 → 484
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:507 → 547
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      84386587..84413927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096760.2 → XP_038952688.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/TrEMBL
      D3ZS84
      Related
      ENSRNOP00000103295.1, ENSRNOT00000151208.1
      Conserved Domains (2) summary
      cd10387
      Location:385 → 484
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:507 → 547
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    2. XM_039096761.2 → XP_038952689.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/TrEMBL
      D3ZS84
      Conserved Domains (2) summary
      cd10387
      Location:385 → 484
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:507 → 547
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    3. XM_039096764.2 → XP_038952692.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/TrEMBL
      D3ZS84
      Related
      ENSRNOP00000054982.4, ENSRNOT00000058179.6
      Conserved Domains (2) summary
      cd10387
      Location:385 → 484
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:507 → 547
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    4. XM_039096763.2 → XP_038952691.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/TrEMBL
      D3ZS84
      Related
      ENSRNOP00000104684.1, ENSRNOT00000135732.1
      Conserved Domains (2) summary
      cd10387
      Location:385 → 484
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:507 → 547
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

    5. XM_039096762.2 → XP_038952690.1  suppressor of cytokine signaling 6 isoform X1

      UniProtKB/TrEMBL
      D3ZS84
      Related
      ENSRNOP00000106191.1, ENSRNOT00000125684.1
      Conserved Domains (2) summary
      cd10387
      Location:385 → 484
      SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03740
      Location:507 → 547
      SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    Nucleotide Protein Strain
    Heading Accession and Version

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