Rrn3 RRN3 homolog, RNA polymerase I transcription factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rrn3provided by RGD
Full Name: RRN3 homolog, RNA polymerase I transcription factorprovided by RGD
Primary source: RGD:1305001
See related: EnsemblRapid:ENSRNOG00000003326 AllianceGenome:RGD:1305001
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305001
Summary: Predicted to enable RNA polymerase I core binding activity; RNA polymerase I core promoter sequence-specific DNA binding activity; and RNA polymerase I general transcription initiation factor activity. Involved in positive regulation of neuron projection development. Predicted to be located in nucleolus. Predicted to be active in nucleus. Orthologous to several human genes including RRN3 (RRN3 homolog, RNA polymerase I transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 174.4), Muscle (RPKM 164.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q11

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (2637016..2672338, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (2129949..2165381, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (3170387..3214648)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that Rrn3 must be present when the committed template complex is forming for transcription to occur.
Title: Mammalian Rrn3 is required for the formation of a transcription competent preinitiation complex containing RNA polymerase I.

Submit: New GeneRIF Correction

General gene information

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Markers

AU028790 (e-PCR)
- UniSTS:111983

RH130091 (e-PCR)
- UniSTS:213379

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase I core binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase I core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase I general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase I general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase I preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytoplasm organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleolus organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ribosome biogenesis	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase I promoter	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transcription initiation at RNA polymerase I promoter	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase I promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA polymerase I-specific transcription initiation factor RRN3

Names: RNA polymerase I-specific transcription initiation factor RRN3-like; RRN3 RNA polymerase I transcription factor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135846.1 → NP_001129318.1 RNA polymerase I-specific transcription initiation factor RRN3

See identical proteins and their annotated locations for NP_001129318.1

Status: PROVISIONAL

Source sequence(s)

BC166485

UniProtKB/TrEMBL

B2GV13

Conserved Domains (1) summary

pfam05327
Location:54 → 588

RRN3; RNA polymerase I specific transcription initiation factor RRN3