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    Gnb5 G protein subunit beta 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83579, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gnb5provided by RGD
    Official Full Name
    G protein subunit beta 5provided by RGD
    Primary source
    RGD:620759
    See related
    EnsemblRapid:ENSRNOG00000047799 AllianceGenome:RGD:620759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GTPase activating protein binding activity. Predicted to be involved in G protein-coupled dopamine receptor signaling pathway; negative regulation of voltage-gated calcium channel activity; and positive regulation of GTPase activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; dark adaptation; and light adaption. Located in cell body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in intellectual developmental disorder with cardiac arrhythmia. Orthologous to human GNB5 (G protein subunit beta 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 284.2), Heart (RPKM 77.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gnb5 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (84956629..84985576)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (76076120..76105069)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (82248951..82286493)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene myosin VA Neighboring gene small nucleolar RNA U3 Neighboring gene myosin VC Neighboring gene Bcl2-like 10 Neighboring gene mitogen-activated protein kinase 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC105255

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein gamma-subunit binding  
    enables G-protein gamma-subunit binding  
    enables G-protein gamma-subunit binding  
    enables GTPase activating protein binding PubMed 
    enables GTPase activator activity  
    contributes_to GTPase activator activity  
    enables GTPase activator activity  
    contributes_to GTPase activator activity  
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding  
    enables signaling receptor complex adaptor activity  
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway  
    involved_in G protein-coupled dopamine receptor signaling pathway  
    involved_in G protein-coupled dopamine receptor signaling pathway  
    involved_in G protein-coupled dopamine receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in dark adaptation  
    acts_upstream_of_or_within dark adaptation  
    involved_in light adaption  
    acts_upstream_of_or_within light adaption  
    involved_in negative regulation of voltage-gated calcium channel activity  
    involved_in negative regulation of voltage-gated calcium channel activity  
    involved_in positive regulation of GTPase activity  
    involved_in signal transduction  
    Items 1 - 20 of 22
    Component Evidence Code Pubs
    located_in cell body PubMed 
    located_in cell tip  
    is_active_in cell tip  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite  
    is_active_in dendrite  
    part_of heterotrimeric G-protein complex  
    part_of heterotrimeric G-protein complex PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in parallel fiber to Purkinje cell synapse  
    is_active_in parallel fiber to Purkinje cell synapse  
    located_in plasma membrane  
    located_in postsynaptic membrane  
    is_active_in postsynaptic membrane  
    is_active_in presynapse  
    located_in presynaptic membrane  
    is_active_in presynaptic membrane  
    part_of protein-containing complex PubMed 
    is_active_in synapse  
    Items 1 - 20 of 22

    General protein information

    Preferred Names
    guanine nucleotide-binding protein subunit beta-5
    Names
    gbeta5
    guanine nucleotide binding protein (G protein), beta 5
    guanine nucleotide binding protein (G protein), beta polypeptide 5
    guanine nucleotide binding protein, beta 5
    guanine nucleotide-binding protein, beta-5 subunit
    transducin beta chain 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031770.4NP_113958.1  guanine nucleotide-binding protein subunit beta-5

      See identical proteins and their annotated locations for NP_113958.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P62882, Q5FWS8
      UniProtKB/TrEMBL
      A6I1C4, Q45QL0
      Related
      ENSRNOP00000066690.3, ENSRNOT00000075708.4
      Conserved Domains (2) summary
      cd00200
      Location:56353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:66103
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      84956629..84985576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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