Agmat agmatinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Agmatprovided by RGD
Full Name: agmatinaseprovided by RGD
Primary source: RGD:1308424
See related: EnsemblRapid:ENSRNOG00000012315 AllianceGenome:RGD:1308424
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines. Predicted to be involved in putrescine biosynthetic process from arginine, using agmatinase. Predicted to be located in mitochondrion. Orthologous to human AGMAT (agmatinase (putative)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 208.4), Kidney (RPKM 140.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (159326680..159357300)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (154043665..154074278)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (160306754..160321951)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of agmatinase manipulates the affective state of rats subjected to chronic restraint stress.
Title: The expression of agmatinase manipulates the affective state of rats subjected to chronic restraint stress.
pre- and postsynaptic expression of agmatinase in rats supports a proposed role in the modulation of the neurotransmitter agmatin.
Title: Synaptic localisation of agmatinase in rat cerebral cortex revealed by virtual pre-embedding.
Agmatinase activity was predominantly detected in neurons of rat and human brain.
Title: The agmatine-degrading enzyme agmatinase: a key to agmatine signaling in rat and human brain?
Agmatinase activity is adscribed to a novel protein with an active site that promiscuously catalyzes a reaction other than the one it evolved to catalyze.
Title: Cloning and functional expression of a rodent brain cDNA encoding a novel protein with agmatinase activity, but not belonging to the arginase family.

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General gene information

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Markers

RH130343 (e-PCR)
- UniSTS:213627

BF398785 (e-PCR)
- UniSTS:246912

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables agmatinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arginase activity	ISO Inferred from Sequence Orthology more info
enables arginase activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanidinobutyrase activity	ISO Inferred from Sequence Orthology more info
enables guanidinobutyrase activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanidinopropionase activity	ISO Inferred from Sequence Orthology more info
enables guanidinopropionase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in putrescine biosynthetic process from arginine, using agmatinase	IBA Inferred from Biological aspect of Ancestor more info
involved_in urea cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanidino acid hydrolase, mitochondrial

Names: AUH; agmatinase, mitochondrial; agmatine ureohydrolase (agmatinase); arginase, mitochondrial; guanidinobutyrase, mitochondrial; guanidinopropionase, mitochondrial

NP_001041650.1

EC 3.5.3.1

EC 3.5.3.17

EC 3.5.3.7

XP_038965617.1

EC 3.5.3.1

EC 3.5.3.17

EC 3.5.3.7

XP_038965618.1

EC 3.5.3.1

EC 3.5.3.17

EC 3.5.3.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048185.1 → NP_001041650.1 guanidino acid hydrolase, mitochondrial precursor

See identical proteins and their annotated locations for NP_001041650.1

Status: PROVISIONAL

Source sequence(s)

BC105628

UniProtKB/Swiss-Prot

Q0D2L3, Q5BK25

UniProtKB/TrEMBL

A6ITV7

Related

ENSRNOP00000016646.3, ENSRNOT00000016648.7

Conserved Domains (1) summary

cd11592
Location:57 → 344

Agmatinase_PAH; Agmatinase-like family includes proclavaminic acid amidinohydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

159326680..159357300

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109690.2 → XP_038965618.1 guanidino acid hydrolase, mitochondrial isoform X2

Conserved Domains (1) summary

cd11592
Location:1 → 241

Agmatinase_PAH; Agmatinase-like family includes proclavaminic acid amidinohydrolase
XM_039109689.2 → XP_038965617.1 guanidino acid hydrolase, mitochondrial isoform X1

Conserved Domains (1) summary

cl17011
Location:57 → 241

Arginase_HDAC; Arginase-like and histone-like hydrolases