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    Apobr apolipoprotein B receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499264, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Apobrprovided by RGD
    Official Full Name
    apolipoprotein B receptorprovided by RGD
    Primary source
    RGD:1565169
    See related
    EnsemblRapid:ENSRNOG00000017403 AllianceGenome:RGD:1565169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Apob48r; RGD1565169
    Summary
    Predicted to enable apolipoprotein receptor activity; protein homodimerization activity; and very-low-density lipoprotein particle receptor activity. Predicted to be involved in triglyceride metabolic process. Predicted to act upstream of or within vesicle-mediated transport. Orthologous to human APOBR (apolipoprotein B receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 49.2), Lung (RPKM 35.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Apobr in Genome Data Viewer
    Location:
    1q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190599595..190603782)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181169019..181173206)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (197999209..198003839)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit C Neighboring gene U6 spliceosomal RNA Neighboring gene CLN3 lysosomal/endosomal transmembrane protein, battenin Neighboring gene interleukin 27 Neighboring gene RNA, U2 small nuclear 62 Neighboring gene ribosomal protein L36A, pseudogene 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The murine macrophage apoB-48 receptor gene (Apob-48r): homology to the human receptor. Brown ML, et al. J Lipid Res, 2002 Aug. PMID 12177162
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables apolipoprotein receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very-low-density lipoprotein particle receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables very-low-density lipoprotein particle receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apolipoprotein B receptor
    Names
    apolipoprotein B-100 receptor
    apolipoprotein B48 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395126.1 → NP_001382055.1  apolipoprotein B receptor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K7M4, A6I994
      Related
      ENSRNOP00000074267.1, ENSRNOT00000091065.3
      Conserved Domains (1) summary
      PTZ00121
      Location:314 → 812
      PTZ00121; MAEBL; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190599595..190603782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001109154.1: Suppressed sequence

      Description
      NM_001109154.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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