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    Brme1 break repair meiotic recombinase recruitment factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Brme1provided by RGD
    Official Full Name
    break repair meiotic recombinase recruitment factor 1provided by RGD
    Primary source
    RGD:1306072
    See related
    EnsemblRapid:ENSRNOG00000025796 AllianceGenome:RGD:1306072
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306072
    Summary
    Predicted to enable damaged DNA binding activity. Predicted to be involved in meiosis I; protein localization to site of double-strand break; and spermatogenesis. Predicted to be located in chromosome. Predicted to be active in site of double-strand break. Orthologous to human BRME1 (break repair meiotic recombinase recruitment factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 43.3), Adrenal (RPKM 29.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Brme1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40894821..40916506, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23990049..24011774, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25262064..25283786)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene microRNA 181d Neighboring gene nanos C2HC-type zinc finger 3 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene podocan-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair involved in meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    break repair meiotic recombinase recruitment factor 1
    Names
    uncharacterized protein C19orf57 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400966.1 → NP_001387895.1  break repair meiotic recombinase recruitment factor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I5ZR08
      Related
      ENSRNOP00000029954.7, ENSRNOT00000030658.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40894821..40916506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277962.1 → XP_063134032.1  break repair meiotic recombinase recruitment factor 1 isoform X5

      UniProtKB/TrEMBL
      A6IYA6

    2. XM_006255331.4 → XP_006255393.1  break repair meiotic recombinase recruitment factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006255393.1

      UniProtKB/TrEMBL
      A6IYA6, F1M7E8
      Related
      ENSRNOP00000105447.1, ENSRNOT00000171684.1
      Conserved Domains (1) summary
      pfam15710
      Location:1 → 616
      DUF4671; Domain of unknown function (DUF4671)

    3. XM_063277961.1 → XP_063134031.1  break repair meiotic recombinase recruitment factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZR08

    4. XM_039098080.2 → XP_038954008.1  break repair meiotic recombinase recruitment factor 1 isoform X7

      UniProtKB/TrEMBL
      A6IYA6
      Conserved Domains (1) summary
      pfam15710
      Location:4 → 582
      DUF4671; Domain of unknown function (DUF4671)

    5. XM_039098077.2 → XP_038954005.1  break repair meiotic recombinase recruitment factor 1 isoform X7

      UniProtKB/TrEMBL
      A6IYA6
      Related
      ENSRNOP00000079476.1, ENSRNOT00000109548.2
      Conserved Domains (1) summary
      pfam15710
      Location:4 → 582
      DUF4671; Domain of unknown function (DUF4671)

    6. XM_039098074.2 → XP_038954002.1  break repair meiotic recombinase recruitment factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZU35
      Related
      ENSRNOP00000108359.1, ENSRNOT00000165748.1
      Conserved Domains (1) summary
      pfam15710
      Location:60 → 639
      DUF4671; Domain of unknown function (DUF4671)

    7. XM_017601425.3 → XP_017456914.1  break repair meiotic recombinase recruitment factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y9Q2, A0A8I5ZU35
      Conserved Domains (1) summary
      pfam15710
      Location:60 → 670
      DUF4671; Domain of unknown function (DUF4671)

    8. XM_039098073.2 → XP_038954001.1  break repair meiotic recombinase recruitment factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y9Q2, A0A8I5ZU35
      Conserved Domains (1) summary
      pfam15710
      Location:60 → 670
      DUF4671; Domain of unknown function (DUF4671)

    9. XM_063277964.1 → XP_063134034.1  break repair meiotic recombinase recruitment factor 1 isoform X7

      UniProtKB/TrEMBL
      A6IYA6

    10. XM_063277960.1 → XP_063134030.1  break repair meiotic recombinase recruitment factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y9Q2, A0A8I5ZU35

    11. XM_063277965.1 → XP_063134035.1  break repair meiotic recombinase recruitment factor 1 isoform X7

      UniProtKB/TrEMBL
      A6IYA6
      Related
      ENSRNOP00000077742.1, ENSRNOT00000115206.2

    12. XM_063277963.1 → XP_063134033.1  break repair meiotic recombinase recruitment factor 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZU35

    RNA

    1. XR_005496718.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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